Primary amoebic meningoencephalitis is a rare but fatal central nervous system (CNS) disease caused by the "brain-eating amoeba" Naegleria fowleri. A major obstacle is the requirement for drugs with the ability to cross the blood-brain barrier, which are used in extremely high doses, cause severe side effects, and are usually ineffective. We discovered that the 4-aminomethylphenoxy-benzoxaborole AN3057 exhibits nanomolar potency against N. fowleri, and experimental treatment of infected mice significantly prolonged survival and demonstrated a 28% relapse-free cure rate.

• Klíčová slova
• Naegleria fowleri, amoeba, antiparasitic, oxaborole, primary amoebic meningoencephalitis,
• MeSH
• amébiáza * farmakoterapie   MeSH
• hematoencefalická bariéra MeSH
• meningoencefalitida * MeSH
• myši MeSH
• Naegleria fowleri * MeSH
• protozoární infekce centrálního nervového systému * farmakoterapie   MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH