Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.

• Klíčová slova
• Anion Channels, Anion transport, Bambusurils, Macrocycles, Supramolecular Chemistry,
• MeSH
• anionty chemie   metabolismus   MeSH
• cholesterol * chemie   metabolismus   MeSH
• iontový transport MeSH
• lipidové dvojvrstvy chemie   metabolismus   MeSH
• liposomy chemie   metabolismus   MeSH
• žlučové kyseliny a soli * chemie   metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• anionty MeSH
• cholesterol * MeSH
• lipidové dvojvrstvy MeSH
• liposomy MeSH
• žlučové kyseliny a soli * MeSH