Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.

College of Chemistry Fuzhou University Fuzhou Fujian 350116 China

Department of Chemistry Faculty of Science Masaryk University Kamenice 5 625 00 Brno Czech Republic

Engineering of Molecular NanoSystems École Polytechnique de Bruxelles Université Libre de Bruxelles Avenue F D Roosevelt 50 CP165 64 1050 Brussels Belgium

RECETOX Faculty of Science Masaryk University Kamenice 5 625 00 Brno Czech Republic

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