Nejvíce citovaný článek - PubMed ID 37710273
Wild ungulates as sentinels of flaviviruses and tick-borne zoonotic pathogen circulation: an Italian perspective
The European subtype of tick-borne encephalitis virus (TBEV-Eur; species Orthoflavivirus encephalitidis, family Flaviviridae) was the only tick-borne flavivirus present in central Europe known to cause neurologic disease in humans and several animal species. Here, we report a tick-borne flavivirus isolated from Alpine chamois (Rupicapra rupicapra rupicapra) with encephalitis and attached ticks, present over a wide area in the Alps. Cases were detected in 2017 in Salzburg, Austria, and 2023 in Lombardy and Piedmont, Italy. The virus strains exhibit 94.8-97.3% nucleotide identities to each other and are more closely related to Louping ill viruses (LIV; Orthoflavivirus loupingi; 90-92% identities) than to TBEV-Eur (less than 88%). The chamois-derived virus strains, tentatively termed "Alpine chamois encephalitis virus", form a well-supported independent genetic clade with Spanish goat encephalitis virus, clearly separated from other LIV. This supports its designation as a new virus subtype with the proposed shared taxonomic name "Spanish goat and Alpine chamois encephalitis virus subtype" within the species Orthoflavivirus loupingi. The zoonotic potential of this newly identified virus subtype as well as its host range in other animal species including farm animals needs to be further investigated.
- Klíčová slova
- Alpine chamois, Flaviviridae, Ixodes ricinus, Rupicapra rupicapra, Spanish goat encephalitis virus, encephalitis, flavivirus, louping ill virus, neurotropic, tick-borne encephalitis virus,
- MeSH
- Flavivirus izolace a purifikace klasifikace genetika MeSH
- fylogeneze * MeSH
- genom virový MeSH
- infekce viry z rodu Flavivirus veterinární virologie epidemiologie MeSH
- klíšťata virologie MeSH
- klíšťová encefalitida virologie MeSH
- nemoci koz virologie MeSH
- Rupicapra * virologie MeSH
- viry klíšťové encefalitidy * izolace a purifikace klasifikace genetika MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Itálie MeSH
- Rakousko MeSH
