Corneal repair using mesenchymal stem cell therapy faces challenges due to long-term cell survival issues. Here, we design cerium oxide with gold single-atom-based nanorobots (CeSAN-bots) for treating corneal damage in a synergistic combination with stem cells. Powered by glucose, CeSAN-bots exhibit enhanced diffusion and active motion due to the cascade reaction catalyzed by gold and cerium oxide. CeSAN-bots demonstrate a two-fold increase in cellular uptake efficiency into mesenchymal stem cells compared to passive uptake. CeSAN-bots possess intrinsic antioxidant and immunomodulatory properties, promoting corneal regeneration. Validation in a mouse corneal alkali burn model reveals an improvement in corneal clarity restoration when stem cells are incorporated with CeSAN-bots. This work presents a strategy for developing glucose-driven, enzyme-free, single-atom-based ultrasmall nanorobots with promising applications in targeted intracellular delivery in diverse biological environments.

• Klíčová slova
• cerium oxide, cornea, glucose, mesenchymal stem cells, nanorobot, single-atom,
• MeSH
• cer chemie   MeSH
• koloidy chemie   MeSH
• lidé MeSH
• mezenchymální kmenové buňky cytologie   MeSH
• myši MeSH
• poranění rohovky * terapie   patologie   MeSH
• transplantace mezenchymálních kmenových buněk * MeSH
• zlato chemie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• cer MeSH
• ceric oxide MeSH Prohlížeč
• koloidy MeSH
• zlato MeSH