The strong effects of bilirubin on various levels of the immune system are multifactorial. Concerning the mechanisms of these effects, we hypothesize that the primary causes of the described actions of bilirubin are the direct interaction of bilirubin molecules with cell membranes.

• MeSH
• bilirubin imunologie   farmakologie   MeSH
• imunosupresiva farmakologie   MeSH
• lidé MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• bilirubin MeSH
• imunosupresiva MeSH

The effect of an i.p. application of bilirubin on phagocytic activity and the arrangement of the microtubule system of murine peritoneal macrophages were examined. A significant increase of phagocytic activity was observed 3 h after bilirubin treatment, and normal value were reached after 3 d. The increase of the extent of the microtubule system was comparable with that of enhanced phagocytosis but normal values were observed after 1 d.

• MeSH
• bilirubin farmakologie   MeSH
• fagocytóza účinky léků   MeSH
• makrofágy účinky léků   fyziologie   MeSH
• mikrotubuly účinky léků   metabolismus   fyziologie   MeSH
• myši inbrední BALB C MeSH
• myši MeSH
• peritoneální dutina cytologie   MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• bilirubin MeSH

The effect of bilirubin on the phagocytic activity of mouse peritoneal macrophages and on the expression of Fc receptors and receptors for SRBC was studied. Intraperitoneally administered bilirubin influenced the expression of Fc receptors for IgM, IgG2B, IgA and IgE, whereas the expression of other receptors as well as the phagocytic activity of peritoneal macrophages remained unchanged. The possible mechanism of the effect of bilirubin on Fc receptors is discussed.

• MeSH
• bilirubin farmakologie   MeSH
• fagocytóza účinky léků   MeSH
• makrofágy účinky léků   imunologie   MeSH
• myši inbrední BALB C MeSH
• myši MeSH
• receptory Fc účinky léků   MeSH
• tvorba rozet MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• bilirubin MeSH
• receptory Fc MeSH