Most cited article - PubMed ID 4007713
Selective decontamination, induced colonization resistance and connected immunological changes in piglets
Fundamental hematological and immunological data were obtained on sexually mature germfree miniature pigs fed, after the milk diet period, with cereal-type diet sterilized by gamma-radiation, and were compared with data of control conventional animals. Germfree adult pigs had a lower count of peripheral blood leukocytes with a lower percentage of neutrophil granulocytes and without any younger forms, a lower total serum protein level with a negligible amount of gamma and alpha 2 globulin fractions and a higher serum albumin and beta globulin level. In the mesenteric lymph nodes and in spleen, surface IgA-bearing cells predominated over surface IgG-bearing cells. Also a large amount of IgA-containing cells was found in the intestinal lamina propria, where the IgG cells were present in a negligible amount. IgM cells were the most frequent surface isotype in peripheral blood. The count of blood T lymphocytes was more than doubled.
- MeSH
- Germ-Free Life * MeSH
- Granulocytes immunology MeSH
- Immune System physiology MeSH
- Immunoglobulins blood physiology MeSH
- Leukocytes immunology MeSH
- Swine, Miniature immunology MeSH
- Swine MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Immunoglobulins MeSH
Peroral administration of Streptococcus faecalis suppresses the lethal effect of simultaneous or subsequent infection with pathogenic Escherichia coli O55 in gnotobiotic colostrum-free piglets. The presence of S. faecalis in the intestine and mesenteric lymph nodes in artificially diassociated colostrum-free piglets influences neither multiplication of E. coli in the intestine nor its penetration into the organism.
