INTRODUCTION: It is well known that platelets from diabetic patients can be resistant to clinically used antiplatelet drugs. METHODS: To assess the phenomenon in more detail, 50 adult patients suffering from type 1 diabetes mellitus (T1D) were recruited and their responses to 7 platelet aggregation inducers, as well as to 3 clinically used antiplatelet drugs (acetylsalicylic acid /ASA/, ticagrelor and vorapaxar) and one experimental compound, 4-methylcatechol, were assessed ex vivo. A control group of 50 generally healthy age-matched controls was also included for comparison. RESULTS: T1D patients exhibited a lower aggregation reaction to 3 inducers but were conversely more resistant to the effect of ASA and vorapaxar than controls. Ticagrelor tended to be less active in T1D as well. On the other hand, 4-methylcatechol was equally or even more potent in T1D than in healthy controls. Plasma glucose levels above 7 mM were associated with lower platelet aggregation responses to four aggregation inducers. In contrast, the effect of 4-methylcatechol, unlike that of ASA, did not appear to be strongly influenced by glycemia. Further subanalyses, excluding hypertensive patients and significantly more frequently administered drugs, did not substantially modify the results. CONCLUSION: Conclusively, 4-methylcatechol seems to be a prototypical antiplatelet compound with a strong effect even in diabetic patients.

• Keywords
• 4-methylcatechol, Aggregation, Diabetes mellitus, Platelets,
• MeSH
• Platelet Aggregation * drug effects   MeSH
• Aspirin * therapeutic use   pharmacology   adverse effects   MeSH
• Diabetes Mellitus, Type 1 * blood   diagnosis   drug therapy   MeSH
• Adult MeSH
• Platelet Aggregation Inhibitors * therapeutic use   adverse effects   pharmacology   MeSH
• Catechols * therapeutic use   pharmacology   MeSH
• Blood Glucose metabolism   drug effects   MeSH
• Lactones * therapeutic use   pharmacology   MeSH
• Drug Resistance MeSH
• Middle Aged MeSH
• Humans MeSH
• Young Adult MeSH
• Pyridines * therapeutic use   pharmacology   MeSH
• Case-Control Studies MeSH
• Ticagrelor therapeutic use   MeSH
• Blood Platelets * drug effects   metabolism   MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Aspirin * MeSH
• Platelet Aggregation Inhibitors * MeSH
• Catechols * MeSH
• Blood Glucose MeSH
• Lactones * MeSH
• Pyridines * MeSH
• Ticagrelor MeSH
• vorapaxar MeSH Browser