The effect of an i.p. application of bilirubin on phagocytic activity and the arrangement of the microtubule system of murine peritoneal macrophages were examined. A significant increase of phagocytic activity was observed 3 h after bilirubin treatment, and normal value were reached after 3 d. The increase of the extent of the microtubule system was comparable with that of enhanced phagocytosis but normal values were observed after 1 d.

• MeSH
• bilirubin farmakologie   MeSH
• fagocytóza účinky léků   MeSH
• makrofágy účinky léků   fyziologie   MeSH
• mikrotubuly účinky léků   metabolismus   fyziologie   MeSH
• myši inbrední BALB C MeSH
• myši MeSH
• peritoneální dutina cytologie   MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• bilirubin MeSH

Properties of macrophages isolated from Peyer's patches were compared with properties of peritoneal macrophages. We found a very low expression of all types of Fc receptors as well as a low expression of Ia antigens on Peyer's patch macrophages. No substantial changes in the levels of FcR and Ia antigen expression were found during the process of ageing. The investigation of phagocytic activity showed the activated state of Peyer's patch macrophages. Comparing the surface markers of lymphocytes obtained from Peyer's patches of mice of different ages, we found no differences in the numbers of sIg+, Thy-+ or L3T4+ lymphocytes. The numbers of FcR+ and Lyt 2.2+ lymphocytes decreased markedly with age.

• MeSH
• fagocytóza MeSH
• lymfocyty imunologie   MeSH
• makrofágy imunologie   MeSH
• MHC antigeny II. třídy analýza   MeSH
• myši inbrední A MeSH
• myši MeSH
• peritoneální dutina imunologie   MeSH
• Peyerovy pláty imunologie   MeSH
• receptory Fc analýza   MeSH
• stárnutí * MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• MHC antigeny II. třídy MeSH
• receptory Fc MeSH