Sporulation was repressed in the parent strain by various carbon sources whereas glucose-resistant mutants were resistant to them but not to glycerol 2-phosphate. Both mycobacillin and dipicolinic acid synthesis were repressed in the parent by some of the compounds tested, viz. glucose, pyruvate and glycerol 2-phosphate. However, these syntheses in the glucose-resistant mutants were not repressed by glucose and pyruvate but were repressed by glycerol 2-phosphate. The possible interrelationship between sporulation, dipicolinic acid and mycobacillin synthesis is discussed in light of these findings.

• MeSH
• Antifungal Agents biosynthesis   MeSH
• Bacillus subtilis metabolism   physiology   MeSH
• Glucose metabolism   MeSH
• Glycerophosphates metabolism   MeSH
• Picolinic Acids biosynthesis   MeSH
• Mycobacillin biosynthesis   MeSH
• Pyruvates metabolism   MeSH
• Spores, Bacterial MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Antifungal Agents MeSH
• dipicolinic acid MeSH Browser
• Glucose MeSH
• Glycerophosphates MeSH
• Picolinic Acids MeSH
• Mycobacillin MeSH
• Pyruvates MeSH

Mycobacillin non-producers, whether sporogenous or asporogenous, possess less exoprotease, but effective exoprotease producers are not always good mycobacillin yielders. There might exist a minimum level of exoprotease formation for elaboration of mycobacillin.

• MeSH
• Antifungal Agents biosynthesis   MeSH
• Bacillus subtilis genetics   metabolism   physiology   MeSH
• Species Specificity MeSH
• Mutation MeSH
• Mycobacillin biosynthesis   MeSH
• Peptide Hydrolases biosynthesis   MeSH
• Spores, Bacterial MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Antifungal Agents MeSH
• Mycobacillin MeSH
• Peptide Hydrolases MeSH

• MeSH
• Adenine metabolism   MeSH
• Agar MeSH
• Alanine pharmacology   MeSH
• Antifungal Agents biosynthesis   MeSH
• Bacillus subtilis growth & development   metabolism   MeSH
• Peptide Biosynthesis MeSH
• Ethanol pharmacology   MeSH
• Ion Exchange MeSH
• Mutation MeSH
• Spores, Bacterial growth & development   MeSH
• Stereoisomerism MeSH
• Ultraviolet Rays MeSH
• Cell Survival MeSH
• Hot Temperature MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Adenine MeSH
• Agar MeSH
• Alanine MeSH
• Antifungal Agents MeSH
• Ethanol MeSH

• MeSH
• Amino Acids metabolism   pharmacology   MeSH
• Bacillus megaterium drug effects   enzymology   growth & development   metabolism   MeSH
• Bacterial Proteins biosynthesis   MeSH
• Nitrates metabolism   MeSH
• Nitrogen metabolism   MeSH
• Carbon Isotopes MeSH
• Quaternary Ammonium Compounds metabolism   MeSH
• Leucine metabolism   MeSH
• Peptide Hydrolases metabolism   MeSH
• Calcium pharmacology   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Amino Acids MeSH
• Bacterial Proteins MeSH
• Nitrates MeSH
• Nitrogen MeSH
• Carbon Isotopes MeSH
• Quaternary Ammonium Compounds MeSH
• Leucine MeSH
• Peptide Hydrolases MeSH
• Calcium MeSH

• MeSH
• Bacillus subtilis enzymology   MeSH
• Centrifugation, Density Gradient MeSH
• Chromatography, Gel MeSH
• Peptide Hydrolases analysis   metabolism   MeSH
• Spores * MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Peptide Hydrolases MeSH