We report that the cloned DNA harboring the long terminal repeat (LTR), v-src, LTR proviral structure is tumorigenic in chickens of the Prague congenic lines. The growth rate of these tumors is by far the highest in the recombinant CC.R1 line, the B haplotype of which is composed of the B-F/L4 and B-G12 subregions originating from different naturally occurring haplotypes. Some of the tumors induced by the LTR, v-src, LTR DNA are repeatedly transplantable in syngeneic chickens, maintain unaltered provirus, and express v-src mRNA. Differences in the response to challenge with Rous sarcoma virus (RSV) and LTR, v-src, LTR DNA on a given experimental model are compared and possible involvement of an interaction between B-F/L and B-G region genes is considered. Regression of the LTR, v-src, LTR DNA-induced tumors did not prevent the formation and growth of tumors induced subsequently by RSV.

• MeSH
• Cell Division genetics   MeSH
• DNA, Neoplasm physiology   MeSH
• Genes, src physiology   MeSH
• Cloning, Molecular MeSH
• Chickens MeSH
• Neoplasms genetics   microbiology   MeSH
• Blotting, Northern MeSH
• Polymorphism, Restriction Fragment Length MeSH
• Proviruses MeSH
• Repetitive Sequences, Nucleic Acid physiology   MeSH
• Blotting, Southern MeSH
• Genetic Complementation Test MeSH
• Avian Sarcoma Viruses MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• DNA, Neoplasm MeSH