Phagocytic activity of peritoneal macrophages of guinea pigs injected subcutaneously with bacterial vaccines was found to be increased. The phagocytic index remained unchanged or was decreased. In addition, a decreased candidacidal activity was observed. Metabolic activation of macrophages, measured by the INT test, was inhibited in unstimulated cells while cells stimulated with zymosan or opsonized zymosan exhibited higher values of the INT test as compared with control animals. After injection of vaccines the number of peritoneal macrophages was increased, but the spleen mass decreased.

• MeSH
• Bacterial Vaccines immunology   MeSH
• Macrophages immunology   metabolism   MeSH
• Guinea Pigs MeSH
• Peritoneum MeSH
• Proteus mirabilis immunology   MeSH
• Staphylococcal Vaccines immunology   MeSH
• Staphylococcus aureus immunology   MeSH
• Animals MeSH
• Check Tag
• Guinea Pigs MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Bacterial Vaccines MeSH
• Staphylococcal Vaccines MeSH