The adherence of group B streptococci (GBS) of serotypes Ia, II and III to human vaginal cells was studied in vitro. The adherence was not dependent on the viability of bacteria; killing of GBS by UV irradiation or glutaraldehyde treatment did not inhibit the adherence. Killing of GBS by heating to 56 degrees C for 1 h led to a pronounced decrease of adherence, demonstrating the thermosensitivity of the GBS structures involved. The protein nature of these structures was proved by a significant reduction of adherence after pretreatment of GBS with trypsin or pepsin. Pretreatment of GBS with sialidase had no influence on the adherence. Such a pretreatment of vaginal cells caused an increase of adherence showing that the receptors on epithelial cells may be partly masked by sialic acid.

• MeSH
• bakteriální adheze * účinky léků   účinky záření   MeSH
• glutaraldehyd farmakologie   MeSH
• lidé MeSH
• neuraminidasa farmakologie   MeSH
• pepsin A farmakologie   MeSH
• Streptococcus agalactiae patogenita   MeSH
• trypsin farmakologie   MeSH
• ultrafialové záření MeSH
• vagina mikrobiologie   MeSH
• vysoká teplota MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• glutaraldehyd MeSH
• neuraminidasa MeSH
• pepsin A MeSH
• trypsin MeSH