Specific interactions of DNA with proteins are required for both the replication of deoxyribonucleic acid proper and its regulation. Genetic elements of bacteria, their extrachromosomal elements in particular, represent a suitable model system for studies of these processes at the molecular level. In addition to replication enzymes (DNA polymerases), a series of other protein factors (e.g. topoisomerases, DNA unwinding enzymes, and DNA binding proteins) are involved in the replication of the chromosomal, phage and plasmid DNA. Specific interactions of proteins with DNA are particularly important in the regulation of initiation of DNA synthesis. Association of DNAs with the cell membrane also plays an important role in their replication in bacteria.

• MeSH
• Chromosomes, Bacterial physiology   MeSH
• Genes, Bacterial MeSH
• Bacterial Proteins genetics   MeSH
• RNA, Bacterial genetics   MeSH
• Bacteriophage phi X 174 genetics   MeSH
• DNA, Bacterial genetics   MeSH
• DNA-Directed RNA Polymerases metabolism   MeSH
• DNA-Directed DNA Polymerase metabolism   MeSH
• DNA biosynthesis   MeSH
• Escherichia coli genetics   metabolism   MeSH
• Plasmids MeSH
• DNA Replication * MeSH
• T-Phages genetics   MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Bacterial Proteins MeSH
• RNA, Bacterial MeSH
• DNA, Bacterial MeSH
• DNA-Directed RNA Polymerases MeSH
• DNA-Directed DNA Polymerase MeSH
• DNA MeSH
• Okazaki fragments MeSH Browser