The biologically based two-stage clonal expansion (TSCE) model is used to analyze lung cancer in several miners studies, two new ones (Czech, French) and two historic ones (Chinese, Colorado). In all cases, the model assumptions are identical. An action of radiation on initiation, promotion, and transformation is allowed. While all four studies indicate a highly significant action of radiation on promotion, the action on initiation is not significant in the French cohort, and barely significant in the Colorado miners cohort. No action on transformation is found in the Colorado miners, while the other data sets indicate a borderline significance. The model can describe all the data sets adequately, with different model parameters. The observed patterns in exposure, time since beginning of exposure, birth year, age and calendar year are reproduced well. The doubling exposure rate for initiation is about 3.5 WLM/year in the new data sets, while it is higher in the historic data sets. For transformation the doubling rate is about 20 WLM/year for the new data sets, while again the historic data give higher estimates. The action of radiation on promotion is quite different in the four data sets. These differences also induce different risk estimates at low exposures. The larger power of the new studies at these low exposures, compared to the historic data requires less extrapolation when the risk at very low exposures is estimated.

• MeSH
• algoritmy MeSH
• biologické modely * MeSH
• dávka záření MeSH
• hodnocení rizik metody   MeSH
• hornictví statistika a číselné údaje   MeSH
• incidence MeSH
• kohortové studie MeSH
• lidé MeSH
• monitorování radiace metody   MeSH
• nádory plic mortalita   MeSH
• nádory vyvolané zářením mortalita   MeSH
• obsah radioaktivních látek v organizmu MeSH
• počítačová simulace MeSH
• proporcionální rizikové modely MeSH
• radon analýza   MeSH
• relativní biologická účinnost MeSH
• rizikové faktory MeSH
• věkové rozložení MeSH
• vztah dávky záření a odpovědi MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky kontrolované MeSH
• klinické zkoušky MeSH
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• validační studie MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH
• Čína epidemiologie   MeSH
• Colorado epidemiologie   MeSH
• Francie epidemiologie   MeSH
• Názvy látek
• radon MeSH

A brief description is given of the study of West Bohemian uranium miners, and recent and ongoing efforts to improve the quality of the data are summarized. Three recent analyses of the data from the cohort have led to rather different estimates of the excess relative risk of mortality from lung cancer per working-level month. The reasons for these different estimates are described, and it is concluded that estimates of lung cancer risk are strongly influenced by the quality of the exposure estimates, especially by the omission of some exposures accumulated during employment at other uranium mines, following the closure of most of the shafts at the original two mines. The most recent analysis has shown that, in common with other cohorts of radon-exposed miners, the excess relative risk of lung cancer per working-level month is modified by age and time since exposure. An inverse effect of exposure rate was also demonstrated, but it affected only men at very high concentrations and appears to be related to the time pattern of exposure. In addition, the risk was found to differ between the two main mines, possibly due to the influence of arsenic in the dust of the mines.

• MeSH
• hornictví * MeSH
• kohortové studie MeSH
• lidé MeSH
• nádory plic etiologie   MeSH
• nádory vyvolané zářením etiologie   MeSH
• radon škodlivé účinky   MeSH
• riziko MeSH
• uran MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• radon MeSH
• uran MeSH