The antifungal effect of substituted 1-phenyl-5-mercaptotetrazoles was tested with Candida tropicalis, C. pseudotropicalis, C. mogii, Trichosporon cutaneum, Cryptococcus albidus and S. cerevisiae. Candida strains exhibited the lowest sensitivity to the compounds; the most sensitive was S. cerevisiae. The MIC values ranged from 40 to > 1000 mg/mL. The antifungal effect of halogenated compounds decreased in the series of bromo > chloro > fluoro derivatives. The electrochemical oxidation of substituted 1-phenyl-5-mercaptotetrazole derivatives in an acetonitrile medium was studied as a model for the enzymic oxidation of the substance, including study of the effect of water, perchloric and trifluoromethanesulfuric acids on E1/2 and I1. 5-Bis-(1-phenyltetrazolyl)disulfide, the compound with no antifungal effect, has been identified as the main oxidation product of 1-phenyl-5-mercaptotetrazole.

• MeSH
• acetonitrily metabolismus   MeSH
• antifungální látky farmakologie   MeSH
• disulfidy farmakologie   MeSH
• elektrolýza MeSH
• houby účinky léků   MeSH
• mikrobiální testy citlivosti MeSH
• tetrazoly farmakologie   MeSH
• vysokoúčinná kapalinová chromatografie MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• Názvy látek
• 1-phenyl-5-mercaptotetrazole MeSH Prohlížeč
• acetonitrile MeSH Prohlížeč
• acetonitrily MeSH
• antifungální látky MeSH
• disulfidy MeSH
• tetrazoly MeSH