Disorders of carbohydrate and lipid metabolism have been reported to cluster in patients with essential hypertension and in spontaneously hypertensive rats (SHRs). A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHRs. However, the role of Cd36 and chromosome 4 in the control of blood pressure and systemic cardiovascular risk factors in SHRs is unknown. In the SHR. BN-Il6/Npy congenic strain, we have found that transfer of a segment of chromosome 4 (including Cd36) from the Brown Norway (BN) rat onto the SHR background induces reductions in blood pressure and ameliorates dietary-induced glucose intolerance, hyperinsulinemia, and hypertriglyceridemia. These results demonstrate that a single chromosome region can influence a broad spectrum of cardiovascular risk factors involved in the hypertension metabolic syndrome. However, analysis of Cd36 genotypes in the SHR and stroke-prone SHR strains indicates that the deletion variant of Cd36 was not critical to the initial selection for hypertension in the SHR model. Thus, the ability of chromosome 4 to influence multiple cardiovascular risk factors, including hypertension, may depend on linkage of Cd36 to other genes trapped within the differential segment of the SHR. BN-Il6/Npy strain.

• MeSH
• CD36 Antigens genetics   MeSH
• Cerebrovascular Disorders genetics   physiopathology   MeSH
• Phenotype MeSH
• Genotype MeSH
• Hemodynamics genetics   MeSH
• Hypertension genetics   physiopathology   MeSH
• Insulin blood   genetics   MeSH
• Blood Glucose genetics   metabolism   MeSH
• Rats MeSH
• Lipids blood   genetics   MeSH
• Rats, Inbred BN MeSH
• Rats, Inbred SHR MeSH
• Risk Factors MeSH
• Sequence Deletion MeSH
• Cluster Analysis MeSH
• Animals, Congenic MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Research Support, U.S. Gov't, P.H.S. MeSH
• Names of Substances
• CD36 Antigens MeSH
• Insulin MeSH
• Blood Glucose MeSH
• Lipids MeSH