Among 31 3,4-dihydro-s-triazinobenzimidazole derivatives tested 12 compounds showed in vitro antimicrobial activity against G+ bacteria. Best results were obtained with substances containing naphthyl or halogenated phenyl group on the triazine ring. The tested derivatives had no significant in vitro antimicrobial activity against either the used G- species or fungi.

• MeSH
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents chemistry   pharmacology   MeSH
• Benzimidazoles chemistry   pharmacology   MeSH
• Gram-Negative Bacteria drug effects   MeSH
• Gram-Positive Bacteria drug effects   MeSH
• Fungi drug effects   MeSH
• Microbial Sensitivity Tests MeSH
• Triazines chemistry   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents MeSH
• Benzimidazoles MeSH
• Triazines MeSH

Five trisubstituted quinazolones and eight trisubstituted quinazoline-4-thiones have been tested for antibacterial effects by a microdilution method. Four derivatives exerted a significant effect on E. coli, P. aeruginosa, S. aureus and B. subtilis (IC50 < 100 mg/L). In the bacterium P. aeruginosa six quinazolines showed a higher antibacterial effect than ampicillin. The most sensitive to the effects of the quinazolines was S. aureus; a concentration of 100 mg/L of six derivatives induced a bacteriostatic effect on S. aureus. The quinazoline-4-thiones were generally more active than the quinazolones. All the tested concentrations of the four most effective quinazolines influenced the specific growth rate.

• MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Bacillus subtilis drug effects   MeSH
• Bacteria drug effects   growth & development   MeSH
• Quinazolines chemistry   pharmacology   MeSH
• Escherichia coli drug effects   MeSH
• Microbial Sensitivity Tests MeSH
• Pseudomonas aeruginosa drug effects   MeSH
• Staphylococcus aureus drug effects   MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Comparative Study MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Quinazolines MeSH