Our experience with anaesthetic combination of butyrophenone derivative droperidol (D, 0.8 mg/kg b.w.) + alpha-2-agonist xylazine (X, 5 mg/kg b.w.) + ketamine (X, 35 mg/kg b.w.), in 28 rats (12 female, 8 + 8 male) is described. Anaesthesia protocol started with ether inhalation (5 ml/l air) in a glass bell. When the effect of anaesthesia was evident, droperidol and xylazine with ketamine were administered in an intramuscular injection. At the same time as anaesthetics, atropine (0.05 mg/kg b.w.) was injected subcutaneously. Average time of induction of ether anaesthesia was 45 +/- 30 s. and duration of the surgical stage was 64 +/- 16 s. Average time of recurrence of the position reflex was 120 min. D + X + K anaesthetic combination is safe, cost effective, and it induces good analgesia and myorelaxation. Anaesthetic effect is possible to prolong with half dose of ketamine with half dose of droperidol or xylazine in 30 to 40 min. interval and the next prolongation is possible in 20 min. interval. The presented combination of anaesthetic was used for the soft tissue surgery (laparotomy, thoracotomy, and cannulation of large vessels--a. carotis, v. jugularis), both in experiments and clinical praxis.
- MeSH
- adjuvancia anestetická aplikace a dávkování MeSH
- anestetika disociativní aplikace a dávkování MeSH
- anestetika inhalační MeSH
- droperidol aplikace a dávkování MeSH
- ether MeSH
- inhalační anestezie * MeSH
- injekce intramuskulární MeSH
- ketamin aplikace a dávkování MeSH
- kombinace anestetik aplikace a dávkování MeSH
- krysa rodu Rattus MeSH
- potkani Wistar MeSH
- xylazin aplikace a dávkování MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- adjuvancia anestetická MeSH
- anestetika disociativní MeSH
- anestetika inhalační MeSH
- droperidol MeSH
- ether MeSH
- ketamin MeSH
- kombinace anestetik MeSH
- xylazin MeSH
