OBJECTIVE: To compare changes in oesophageal (T-Oeso) and rectal (T-Rec) temperature in dogs during general anaesthesia and premedicated with fentanyl, medetomidine-fentanyl or acepromazine-fentanyl. STUDY DESIGN: Prospective, randomized, blind clinical study. ANIMALS: A total of 120 healthy dogs, aged 2-10 years and weighing 5-20 kg. METHODS: Dogs were randomly allocated to one of three groups. Animals of F group were premedicated with fentanyl (0.01 mg kg-1), MF group with medetomidine (0.005 mg kg-1) and fentanyl (0.01 mg kg-1) and AF group with acepromazine (0.01 mg kg-1) and fentanyl (0.01 mg kg-1). Anaesthesia was induced with propofol and maintained with isoflurane in oxygen-air mixture. Fentanyl was administered continuously (0.01 mg kg-1 hour-1). The T-Oeso, T-Rec and ambient temperatures were recorded after induction (T0) and subsequently at 10 minute intervals for 60 minutes (T10-T60). Data were analysed using anova or their non-parametric equivalents (p < 0.05). RESULTS: Median T-Oeso was significantly higher in MF group between T0-T20 compared with other groups. Median T-Oeso significantly decreased in F group from 38.0 °C (T0) to 37.4 °C (T30), 37.1 °C (T40), 36.9 °C (T50) and 36.6 °C (T60), in MF group from 38.3 °C (T0) to 37.7 °C (T30), 37.5 °C (T40), 37.2 °C (T50) and 37.1 °C (T60) and in AF group from 37.7 °C (T0) to 37.3 °C (T40), 37.2 °C (T50) and 37.1 °C (T60). The T-Rec significantly decreased in F group from 38.0 °C (T0) to 37.4 °C (T40), 37.2 °C (T50) and 36.9 °C (T60), in MF group from 38.3 °C (T0) to 37.5 °C (T50) and 37.4 °C (T60) and in AF group from 38.2 °C (T0) to 37.6 °C (T40), 37.5 °C (T50) and 37.4 °C (T60). CONCLUSIONS AND CLINICAL RELEVANCE: Premedication with fentanyl, medetomidine-fentanyl or acepromazine-fentanyl in the doses used decreased the T-Oeso and T-Rec. The T-Oeso at the beginning of anaesthesia was higher after premedication with medetomidine-fentanyl. However, this difference was not clinically significant.
- Klíčová slova
- heat loss, hypothermia, neuroleptic, opioid, temperature, α(2)-adrenoceptor agonist,
- MeSH
- acepromazin * farmakologie aplikace a dávkování MeSH
- anestetika intravenózní farmakologie aplikace a dávkování MeSH
- celková anestezie veterinární MeSH
- ezofágus účinky léků MeSH
- fentanyl * farmakologie aplikace a dávkování MeSH
- kombinace anestetik aplikace a dávkování farmakologie MeSH
- medetomidin * farmakologie aplikace a dávkování MeSH
- premedikace anestezie veterinární MeSH
- prospektivní studie MeSH
- psi MeSH
- rektum MeSH
- tělesná teplota * účinky léků MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- psi MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie veterinární MeSH
- Názvy látek
- acepromazin * MeSH
- anestetika intravenózní MeSH
- fentanyl * MeSH
- kombinace anestetik MeSH
- medetomidin * MeSH
THE AIM OF THE STUDY: Recently, alpha2 sympathoadrenergic drugs are used in premedication to improve the perioperative course. The aim of our study was to compare a premedication with a new alpha2 sympathoadrenergic drug and standard premedication. METHODS: After ethic committee approval and written patient consent, in a randomised, double-blinded study, combination of dexmedetomidine 1.0 microg x kg(-1) + ketamine 0.5 mg x kg(-1) + fentanyl 1.0 microg x kg(-1) + atropine 0.5 mg (group FNT), dexmedetomidine 1.0 microg x kg(-1) + ketamine 0.5 mg x kg(-1) + alfentanil 5.0 microg x kg(-1) + atropine 0.5 mg (group ALFNT), or pethidine 1.0 mg x kg(-1) + atropine 0.5 mg (group Dolsin) was administered to a deltoid muscle 15 min. before anaesthesia (GA) in patients elicited for laparoscopic cholecystectomy (LCHE). GA was performed in a standard way, ECG, NIBP, respiration rate, SpO2, onset of effect, Observers Assessment of Alertness Sedation Score (OAASS) before GA, circulatory reaction to intubation and capnoperitoneum, fentanyl consumption during GA, time to the first request for post-operative analgesia and postoperative nausea and vomiting were measured. The data were processed by Kruskal-Wallis and Fisher tests. P-value < 0.05 was considered significant. RESULTS: There were 16 patients in FNT and Dolsin and 15 patients in ALFNT with no differences in demography except for younger age in ALFNT. The main differences were in hypertension during capnoperitoneum: 0/16 FNT and 1/15 ALFNT vs. 11/16 Dolsin, both p < 0.001, per-operative fentanyl consumption: FNT 31.5 microg vs. Dolsin 165.0 microg, p < 0.001 and ALFNT 50.0 microg, p < 0.05 (ALFNT vs. Dolsin, p < 0.01) and request to the first analgesic post surgery: FNT 1.3 h. vs. Dolsin 0.45 h., p < 0.05 vs. ALFNT 0.8 h., p < 0.01. There were no differences in side effects except for bradycardia in ALFNT (p < 0.05). CONCLUSIONS: Dexmedetomidine-ketamine-fentanyl-atropine combination is superior to pethidine-atropine combination in suppressing of adverse hemodynamic effects of capnoperitoneum, decreased need for analgesia during GA and prolonged postoperative analgesia.
- MeSH
- anestetika disociativní aplikace a dávkování MeSH
- atropin aplikace a dávkování MeSH
- cholecystektomie laparoskopická * MeSH
- dexmedetomidin aplikace a dávkování MeSH
- dvojitá slepá metoda MeSH
- fentanyl aplikace a dávkování MeSH
- hemodynamika účinky léků MeSH
- hypnotika a sedativa aplikace a dávkování MeSH
- ketamin aplikace a dávkování MeSH
- kombinace anestetik aplikace a dávkování MeSH
- lidé středního věku MeSH
- lidé MeSH
- meperidin aplikace a dávkování MeSH
- neopioidní analgetika MeSH
- opioidní analgetika aplikace a dávkování MeSH
- pooperační bolest prevence a kontrola MeSH
- probouzení z anestezie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- anestetika disociativní MeSH
- atropin MeSH
- dexmedetomidin MeSH
- fentanyl MeSH
- hypnotika a sedativa MeSH
- ketamin MeSH
- kombinace anestetik MeSH
- meperidin MeSH
- neopioidní analgetika MeSH
- opioidní analgetika MeSH
Our experience with anaesthetic combination of butyrophenone derivative droperidol (D, 0.8 mg/kg b.w.) + alpha-2-agonist xylazine (X, 5 mg/kg b.w.) + ketamine (X, 35 mg/kg b.w.), in 28 rats (12 female, 8 + 8 male) is described. Anaesthesia protocol started with ether inhalation (5 ml/l air) in a glass bell. When the effect of anaesthesia was evident, droperidol and xylazine with ketamine were administered in an intramuscular injection. At the same time as anaesthetics, atropine (0.05 mg/kg b.w.) was injected subcutaneously. Average time of induction of ether anaesthesia was 45 +/- 30 s. and duration of the surgical stage was 64 +/- 16 s. Average time of recurrence of the position reflex was 120 min. D + X + K anaesthetic combination is safe, cost effective, and it induces good analgesia and myorelaxation. Anaesthetic effect is possible to prolong with half dose of ketamine with half dose of droperidol or xylazine in 30 to 40 min. interval and the next prolongation is possible in 20 min. interval. The presented combination of anaesthetic was used for the soft tissue surgery (laparotomy, thoracotomy, and cannulation of large vessels--a. carotis, v. jugularis), both in experiments and clinical praxis.
- MeSH
- adjuvancia anestetická aplikace a dávkování MeSH
- anestetika disociativní aplikace a dávkování MeSH
- anestetika inhalační MeSH
- droperidol aplikace a dávkování MeSH
- ether MeSH
- inhalační anestezie * MeSH
- injekce intramuskulární MeSH
- ketamin aplikace a dávkování MeSH
- kombinace anestetik aplikace a dávkování MeSH
- krysa rodu Rattus MeSH
- potkani Wistar MeSH
- xylazin aplikace a dávkování MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- adjuvancia anestetická MeSH
- anestetika disociativní MeSH
- anestetika inhalační MeSH
- droperidol MeSH
- ether MeSH
- ketamin MeSH
- kombinace anestetik MeSH
- xylazin MeSH
