Sentinel lymph node biopsy (SLNB) has become the preferred method of surgical pathological nodal staging of early breast cancer by the end of the nineties. As the most likely sites of metastasis, the SLNs allow a more precise staging, and indeed gross sectioning, step sectioning, immunohistochemistry, and molecular staging methods have been used to disclose metastatic involvement of these lymph nodes. This review summarizes the backgrounds of SLNB, trends in related surgery and pathology. It also gives an insight into European National recommendations related to SLN and divergent daily practices in European pathology departments, on the basis of replies to questionnaires from 84 pathologists from 38 European countries. The questionnaires revealed the post-neoadjuvant setting as an area where a significant minority of pathologists report less confidence in classifying residual nodal involvement into TNM categories. The review also summarizes the neoadjuvant therapy-related aspects of SLNB.
- Klíčová slova
- Breast cancer, Lymph nodes, Neoadjuvant treatment, Questionnaire, Sentinel lymph nodes,
- MeSH
- axila patologie MeSH
- biopsie sentinelové lymfatické uzliny MeSH
- lidé MeSH
- lymfadenektomie MeSH
- lymfatické metastázy diagnóza patologie MeSH
- lymfatické uzliny patologie MeSH
- nádory prsu * patologie MeSH
- neoadjuvantní terapie MeSH
- sentinelová uzlina * patologie MeSH
- staging nádorů MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
