BACKGROUND: The potential antiatherogenic role of bilirubin is generally acknowledged, so the aim of this study was to determine serum bilirubin concentrations and the prevalence of Gilbert syndrome (GS) in the Czech general population with particular reference to its relationship to the risk of myocardial infarction (MI). METHODS AND RESULTS: Biochemical markers were analyzed in 2 independent Czech post-MONICA studies (in total, n=3,311), and in 741 male MI patients. TheUGT1A1promoter gene variant (rs81753472) was analyzed in these MI patients and in the first control population cohort (n=717). Medians of serum bilirubin concentrations in the 2 Czech general population cohorts were 9.6 and 9.8 μmol/L (10.7 and 11.3 μmol/L in males, and 8.3 and 8.8 μmol/L in females; P<0.01). The prevalence of GS was 8.9%, twice as high in males compared with females (11.6 vs. 6.1%; P<0.01). TheUGT1A1(TA)7/7promoter repeats significantly influenced serum bilirubin concentrations in the controls, but not in the MI patients. Serum bilirubin concentrations were significantly lower in MI patients (7.7 vs. 10.7 μmol/L; P<0.01), with almost 5-fold lower prevalence of GS. CONCLUSIONS: Serum bilirubin concentrations and the prevalence of GS were determined in the Czech general population. Significantly lower serum bilirubin concentrations were observed in male MI patients.

• Klíčová slova
• Bilirubin, Cardiovascular diseases, Gilbert syndrome, Myocardial infarction, UGT1A1 promoter gene variants,
• MeSH
• bilirubin krev   MeSH
• dospělí MeSH
• genotyp MeSH
• Gilbertova nemoc krev   epidemiologie   genetika   MeSH
• glukuronosyltransferasa genetika   MeSH
• infarkt myokardu krev   epidemiologie   genetika   MeSH
• lidé středního věku MeSH
• lidé MeSH
• polymorfismus genetický MeSH
• prevalence MeSH
• promotorové oblasti (genetika) MeSH
• prospektivní studie MeSH
• průřezové studie MeSH
• retrospektivní studie MeSH
• rizikové faktory MeSH
• sexuální faktory MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH
• Názvy látek
• bilirubin MeSH
• glukuronosyltransferasa MeSH
• UGT1A1 enzyme MeSH Prohlížeč

Coronary artery anomalies represent a diverse group of congenital disorders characterized by abnormalities of coronary arteries anatomy. We describe an extremely rare case of giant torturous left circumflex artery draining to the right atrium manifesting by palpitations and atrial fibrillation.

• Klíčová slova
• computed tomography, coronary artery fistula, echocardiography,
• MeSH
• anomálie koronárních cév diagnóza   MeSH
• diferenciální diagnóza MeSH
• echokardiografie transezofageální MeSH
• koronární angiografie MeSH
• koronární cévy diagnostické zobrazování   MeSH
• lidé MeSH
• počítačová rentgenová tomografie MeSH
• senioři MeSH
• srdeční síně abnormality   diagnostické zobrazování   MeSH
• stupeň závažnosti nemoci MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH