Twenty-three patients with fondaparinux prophylaxis over 75 years of age who underwent hip fracture surgery were enrolled in the study. Fondaparinux sodium (2.5 mg) was administered subcutaneously 6 h postoperatively and then every 24 h for 28 days. Coagulation and inflammatory parameters were measured preoperatively, then 10 h, 2, 7, and 28 days postoperatively. Increased D-dimers, positive acute phase proteins, and IL-6, and decreased negative acute phase proteins were observed preoperatively (P < 0.05). Maximum values were reached 10 h postoperatively for IL-6 and D-dimer, and on postoperative days 2 and 7 for positive acute phase proteins (P < 0.05). Transferrin, prealbumin and antithrombin levels were lowest 10 h postoperatively and on postoperative day 2 (P < 0.05). Increased D-dimers, IL-6, and positive acute phase proteins, and decreased negative acute phase proteins persisted until postoperative day 28 (P < 0.05). Prothrombin fragments (F1 + 2) reached peak levels preoperatively and decreased gradually until postoperative day 28. Fondaparinux promoted the inhibition of thrombin generation, as documented by negative correlation between F1 + 2 and FXa inhibition (r = -0.46; P < 0.001). Fondaparinux-induced FXa inhibition increased gradually until postoperative day 28. This increase correlated positively with antithrombin activity (r = 0.4; P < 0.05). Fondaparinux prophylaxis counteracted pro-thrombogenic effect associated with hip fracture and subsequent surgery without severe bleeding complications.

• MeSH
• antikoagulancia aplikace a dávkování   terapeutické užití   MeSH
• časové faktory MeSH
• fondaparinux MeSH
• fraktury kyčle krev   chirurgie   MeSH
• hemokoagulace účinky léků   MeSH
• inhibitory faktoru Xa * MeSH
• injekce subkutánní MeSH
• lidé MeSH
• mediátory zánětu krev   MeSH
• polysacharidy aplikace a dávkování   terapeutické užití   MeSH
• pooperační komplikace prevence a kontrola   MeSH
• proteiny akutní fáze analýza   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• vyšetření krevní srážlivosti MeSH
• žilní tromboembolie prevence a kontrola   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antikoagulancia MeSH
• fondaparinux MeSH
• inhibitory faktoru Xa * MeSH
• mediátory zánětu MeSH
• polysacharidy MeSH
• proteiny akutní fáze MeSH