Naringenin (PubChem CID 932) Dotaz Zobrazit nápovědu
Flavonoids are known to have effects on cytochrome P450 enzymatic activity. However, little effort has been made to examine species differences and the relevance of studies on mammalian and fish microsomes so that extrapolations can be made to humans. Therefore, the effects of several naturally occurring flavonoids on the activity of CYP3A-dependent 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase (BFCOD) were evaluated in human, pig, mouse, and juvenile rainbow trout sources of hepatic microsomes. Each was exposed to three concentrations (1, 10, and 100μM) of diosmin, naringin, and naringenin. Naringenin competitively inhibited BFCOD activity (Ki values were 24.6μM in human, 15.6μM in pig, and 19.6μM in mouse microsomes). In fish, BFCOD activity was inhibited in a noncompetitive manner (Ki=7μM). Neither diosmin nor naringenin affected BFCOD activity in hepatic microsomes from the studied model organisms. These results suggest that dietary flavonoids potentially inhibit the metabolism of clinical drugs.
- Klíčová slova
- CYP3A, Diosmin, Diosmin (PubChem CID: 5353588), Inhibition, Naringenin, Naringenin (PubChem CID: 932), Naringin, Naringin (PubChem CID: 25075),
- MeSH
- Citrus chemie MeSH
- cytochrom P-450 CYP3A genetika metabolismus MeSH
- diosmin farmakologie MeSH
- druhová specificita MeSH
- exprese genu MeSH
- flavanony farmakologie MeSH
- hydrolýza MeSH
- inhibitory enzymů farmakologie MeSH
- jaterní mikrozomy účinky léků enzymologie MeSH
- játra účinky léků enzymologie MeSH
- kinetika MeSH
- kumariny metabolismus MeSH
- lidé MeSH
- myši inbrední ICR MeSH
- myši MeSH
- Oncorhynchus mykiss MeSH
- prasata MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 7-benzyloxy-4-trifluoromethylcoumarin MeSH Prohlížeč
- cytochrom P-450 CYP3A MeSH
- diosmin MeSH
- flavanony MeSH
- inhibitory enzymů MeSH
- kumariny MeSH
- naringenin MeSH Prohlížeč
- naringin MeSH Prohlížeč
