The present study describes the effect of kynurenic (KYNA) and 5,7-dichlorokynurenic (DCKA) acids, acting as selective antagonists at the glycine site on the NMDA receptor complex, upon short-term memory of male rats. Oxiracetam (OXIR) or pramiracetam (PRAM) were used as reference compounds. In the social recognition test, adult animals were injected SC with a drug or vehicle immediately after the first exposure to a juvenile male, 21-24 days old, and reexposed to the same or a novel juvenile 120 min later. Time spent by adults in social investigation of juveniles was measured. Animals treated with KYNA or DCKA (0.3, 3 and 30 mg/kg in both cases) and OXIR (30 and 60 mg/kg) had significantly reduced investigation time when reexposed to the same juvenile as compared to controls. No reduction of investigation time was found in those drugged animals reexposed to a novel juvenile. The findings suggest that KYNA and DCKA improved retention of memory for olfactory stimuli in adult male rats. In the object recognition test, the duration of exploration of two identical objects during the sample trial and the familiar and a new object during the choice trial, performed 60 min later, was evaluated. Drugs or vehicles were administered SC 30 min prior to the sample trial. On choice one, animals treated with KYNA or DCKA (0.6 and 30 mg/kg in both cases) and PRAM (30 mg/kg) spent more time in exploring a new object than the familiar one as compared to controls. This suggests that the drugged animals were able to remember the familiar object.(ABSTRACT TRUNCATED AT 250 WORDS)

• MeSH
• antagonisté excitačních aminokyselin farmakologie   MeSH
• časové faktory MeSH
• habituace (psychofyziologie) účinky léků   MeSH
• krátkodobá paměť účinky léků   MeSH
• krysa rodu Rattus MeSH
• kyselina kynurenová analogy a deriváty   farmakologie   MeSH
• potkani Wistar MeSH
• sociální identifikace * MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• 5,7-dichlorokynurenic acid MeSH Prohlížeč
• antagonisté excitačních aminokyselin MeSH
• kyselina kynurenová MeSH

Quinolinic acid (QUIN) displaced binding of agonist and antagonist ligands for the N-methyl-D-aspartate (NMDA) receptor in rat brain synaptic membranes. Both QUIN and glutamic acid (GLU) potentiated binding of [3H]dizocilpine (MK-801) in the presence of glycine (GLY) alone, whereas the potentiation by QUIN was in a bell-shaped fashion in contrast to that by GLU. However, further addition of spermidine (SPD) induced bell-shaped potentiation by GLU as well as QUIN. The potentiation by QUIN was markedly deteriorated by the further addition of FeCl2 irrespective of the presence of GLY and SPD added. These results suggest that QUIN may potentiate [3H]MK-801 binding to the open NMDA channel in rat brain synaptic membranes through a mechanism different from that underlying the potentiation by GLU.

• MeSH
• 2-amino-5-fosfonovalerát analogy a deriváty   farmakologie   MeSH
• alosterická regulace MeSH
• antagonisté excitačních aminokyselin farmakologie   MeSH
• dizocilpinmaleát metabolismus   MeSH
• glycin farmakologie   MeSH
• inhibiční koncentrace 50 MeSH
• krysa rodu Rattus MeSH
• kyselina chinolinová antagonisté a inhibitory   metabolismus   farmakologie   MeSH
• kyselina glutamová metabolismus   farmakologie   MeSH
• kyselina kynurenová analogy a deriváty   farmakologie   MeSH
• mozek cytologie   metabolismus   MeSH
• potkani Wistar MeSH
• receptory N-methyl-D-aspartátu agonisté   antagonisté a inhibitory   metabolismus   MeSH
• spermidin farmakologie   MeSH
• synaptické membrány metabolismus   MeSH
• vazebná místa MeSH
• železnaté sloučeniny farmakologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• Názvy látek
• 2-amino-5-fosfonovalerát MeSH
• 5,7-dichlorokynurenic acid MeSH Prohlížeč
• antagonisté excitačních aminokyselin MeSH
• CGP 39653 MeSH Prohlížeč
• dizocilpinmaleát MeSH
• ferrous chloride MeSH Prohlížeč
• glycin MeSH
• kyselina chinolinová MeSH
• kyselina glutamová MeSH
• kyselina kynurenová MeSH
• receptory N-methyl-D-aspartátu MeSH
• spermidin MeSH
• železnaté sloučeniny MeSH