A high level of c-myc gene expression was found to be a constant feature of v-src transformation. The c-myc gene product was analyzed in quail embryo cells transformed by different mutants of Rous sarcoma virus (RSV) that were temperature-sensitive with respect to various parameters of v-src function. The high-level expression of c-myc proved not to be temperature-sensitive: at both permissive (35 degrees C) and non-permissive (41 degrees C) temperatures, the same high levels of c-myc gene product were found for all RSV mutants tested. This result, in agreement with earlier evidence for a v-src-induced proliferative stimulus which was unaffected by ts mutants at the non-permissive temperature, shows that certain v-src functions have not yet been fully characterized.

• MeSH
• aktivace transkripce MeSH
• Coturnix embryologie   mikrobiologie   MeSH
• fenotyp MeSH
• geny myc genetika   MeSH
• protoonkogenní proteiny c-myc genetika   metabolismus   MeSH
• ptačí sarkom genetika   mikrobiologie   MeSH
• regulace exprese virových genů genetika   MeSH
• regulace genové exprese u nádorů genetika   MeSH
• senzitivita a specificita MeSH
• teplota MeSH
• virová transformace buněk genetika   MeSH
• viry ptačího sarkomu genetika   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• protoonkogenní proteiny c-myc MeSH