The authors studied combined effect of aniline (20 mg/kg for a period of 4 weeks in drinking water) and nitrosodimethylamine (NDMA) (30 mg/kg, a single intragastric dose) on the activity of enzymes of different subcellular structures: endoplasmic reticulum (cytochromes P450, B5, acetylesterase), mitochondria (malate dehydrogenase) and the content of N-acetylneuraminic acid in rat liver and of lysosomes (beta-glucuronidase, beta-galactosidase). The combined action of NDMA and aniline was accompanied by more pronounced changes in the indices under investigation than isolated administration of the given chemical substances. The most pronounced aggravation of the unfavourable changes was observed in the activity of enzymes connected with the processes of oxidation and energy supply to the cell (malate dehydrogenase) and the metabolism of glucuronides (beta-glucuronidase) as well as in the content of N-acetylneuraminic acid. This may be connected with the modifying effect of aniline on the toxic effect of NDMA.

• MeSH
• acetylesterasa metabolismus   MeSH
• aniliny farmakologie   MeSH
• beta-galaktosidasa metabolismus   MeSH
• dimethylnitrosamin farmakologie   MeSH
• glukuronidasa metabolismus   MeSH
• jaterní mikrozomy enzymologie   MeSH
• játra enzymologie   metabolismus   ultrastruktura   MeSH
• krysa rodu Rattus MeSH
• kyseliny sialové metabolismus   MeSH
• lyzozomy enzymologie   MeSH
• malátdehydrogenasa metabolismus   MeSH
• systém (enzymů) cytochromů P-450 metabolismus   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• acetylesterasa MeSH
• aniline MeSH Prohlížeč
• aniliny MeSH
• beta-galaktosidasa MeSH
• dimethylnitrosamin MeSH
• glukuronidasa MeSH
• kyseliny sialové MeSH
• malátdehydrogenasa MeSH
• systém (enzymů) cytochromů P-450 MeSH