Serum and coagulum antibiotic levels have a parallel course. Coagulum antibiotic concentrations are more than ten times lower than serum concentrations. Therefore the optimal dosage of perioperative infusion should be high enough to establish steady state by means of sufficiently high serum levels. Antibiotics capable of attaining high serum levels and having a long half-life are best suited for the formation of effective antibiotic concentrations in blood coagulum. This is particularly true for cephalosporins and penicillins. Aminoglycoside antibiotics are not recommended for the formation of protected coagulum. "Ceftriaxon in the treatment of Severe bacterial infections".

• MeSH
• antibakteriální látky krev   farmakologie   MeSH
• hemokoagulace * účinky léků   MeSH
• králíci MeSH
• oxacilin krev   farmakologie   MeSH
• vazba proteinů účinky léků   MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antibakteriální látky MeSH
• oxacilin MeSH