Warmth and heat are registered by different types of cutaneous receptors. To disentangle the cortical activation patterns of warming and heating, we analyzed the temporal evolution of the electroencephalographic 10 and 20 Hz oscillations with the time resolution of hundreds of milliseconds. Sixty heat (from 32 to 50.5 degrees C, rate of change 6 degrees C/s) and warm (from 32 to 42 degrees C, 6 degrees C/s) stimuli were applied on the right thenar using contact thermode. EEG was recorded from 111 scalp electrodes in 12 healthy subjects, and analyzed using event-related desynchronization and low-resolution electromagnetic tomography methods. During warming, the amplitudes of 10 and 20 Hz oscillations over the contralateral primary sensorimotor (SI/MI) and premotor cortices decreased, and the amplitude of 20 Hz oscillations in the anterior cingulate and ipsilateral premotor cortex increased. Heating was associated with additional profound amplitude decreases of 10 and 20 Hz oscillations over SI/MI and premotor cortex, and by amplitude increase of 20 Hz oscillations originating in the posterior cingulate cortex. Results suggest biphasic amplitude changes of the cortical oscillations during ramp increase of temperature attributable to the periods of warming and heating. The amplitude decreases of 10 and 20 Hz oscillations in SI/MI and premotor cortex possibly aid in preparation of motor withdrawal reaction in an event that temperature should reach intolerable pain. Synchronization of the 20 Hz oscillations in the anterior and especially in the posterior cingulate cortex may aid suppression of unwanted movements.
- MeSH
- Analysis of Variance MeSH
- Adult MeSH
- Electroencephalography methods MeSH
- Evoked Potentials physiology radiation effects MeSH
- Cortical Synchronization * MeSH
- Humans MeSH
- Brain Mapping * MeSH
- Pain Measurement MeSH
- Motor Cortex physiology radiation effects MeSH
- Reaction Time physiology radiation effects MeSH
- Sensory Thresholds MeSH
- Somatosensory Cortex physiology radiation effects MeSH
- Body Temperature Regulation * MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Brief somatosensory stimuli are followed by amplitude decreases (event-related desynchronization, ERD) of the 10 and 20 Hz oscillations over the bilateral primary sensorimotor cortices, and by post-stimulus synchronization (event-related synchronization, ERS) of the 20 Hz oscillations in the contralateral primary sensorimotor cortex and in the supplementary motor area (SMA). The 10 and 20 Hz ERD differentiate weak and strong somatosensory stimuli but not fine intensity gradations, and the ipsilateral ERD is especially sensitive to habituation. Stimulus anticipation, motor imagery, action viewing as well as voluntary movements modulate the stimulus-related changes of cortical oscillations. Noxious laser stimuli, selectively activating Adelta and/or C fibers, and innocuous warm and cold stimuli are associated with 10 and 20 Hz ERD but not with the post-stimulus 20 Hz ERS suggesting that the post-stimulus ERS is only related to neuronal transmission in the lemniscal system. It is proposed that phase-unlocked cortical oscillations modulate the preparedness of a particular sensory channel for upcoming somatosensory processing.