DIURETICS Dotaz Zobrazit nápovědu

Diuretics belong into the group of basic antihypertensive drugs. A number of clinical trials provided evidence that long-term administration of diuretics leads not only to effective control of hypertension but has at the same time a favourable impact on cardiovascular morbidity and mortality. Along with beta-blockers diuretics are recommended as drugs of first choice in patients with arterial hypertension. The author presents a brief account of different groups of diuretics incl. their indications.

MeSH
diuretika škodlivé účinky farmakologie terapeutické užití MeSH
hypertenze farmakoterapie MeSH
lidé MeSH
Check Tag
lidé MeSH
Publikační typ
anglický abstrakt MeSH
časopisecké články MeSH
Názvy látek
diuretika MeSH

Článek

Diuretiká v liecbe hypertenzie
[Diuretics in the treatment of hypertension]

Diuretics are basic antihypertensives indicated in essential and secondary hypertension. ...

Vnitrni lekarstvi. 1996 Feb ; 42 (2) : 106-9.

Vnitr Lek
ISSN 0042-773X
Zdroj

Diuretics are basic antihypertensives indicated in essential and secondary hypertension. Their pharmacodynamics is well known, their therapeutic spectrum is wide, their tolerance is excellent, the cost/benefit is lowest among all contemporary antihypertensives and after re-evaluation of the safety of small doses, diuretics have come to their revival.

Článek

Diuretika
[Diuretics]

Vondrácek, B
Autor Vondrácek, B

Ceskoslovenska farmacie. 1965 Jun ; 14 (5) : 229-37.

Cesk Farm
ISSN 0009-0530
Zdroj

MeSH
diuretika * MeSH
Publikační typ
časopisecké články MeSH
přehledy MeSH
Názvy látek
diuretika * MeSH

Článek

Diuretiká v liecbe hypertenzie
[Diuretics in the treatment of hypertension]

Diuretics are one of the basic groups of antihypertensive drugs. ...

Vnitrni lekarstvi. 1993 Sep ; 39 (9) : 909-15.

Vnitr Lek
ISSN 0042-773X
Zdroj

Diuretics are one of the basic groups of antihypertensive drugs. They have also certain limitations and undesirable effects which are better defined than in other more recently developed antihypertensives. Undesirable effects can be prevented by early combination of saluretics with K+ sparing diuretics or other antihypertensive drugs and by prevention of metabolic disorders (in particular insulin resistance and dyslipoproteinaemia) and by prescription of small doses. Only prospective intervention studies will show whether the advantages of other groups of antihypertensives, as compared with diuretics, will influence the prognosis of patients with essential hypertension in a substantial way. Several studies along these lines are under way.

MeSH
antihypertenziva terapeutické užití MeSH
diuretika terapeutické užití MeSH
hypertenze farmakoterapie MeSH
Publikační typ
anglický abstrakt MeSH
časopisecké články MeSH
přehledy MeSH
Názvy látek
antihypertenziva MeSH
diuretika MeSH

Článek

The effect of diuretics and vasopressin on the osmotic permeability of the frog urinary bladder

concentrations (in mM) of ethacrynic acid (0.1), furosemide (1.0), theophylline (5.0) and osmotic diuretics ...

Physiologia Bohemoslovaca. 1976 ; 25 (6) : 529-34.

Physiol Bohemoslov
ISSN 0369-9463
Zdroj

1. Large concentrations (in mM) of ethacrynic acid (0.1), furosemide (1.0), theophylline (5.0) and osmotic diuretics (100.0) sharply increased the flux of water along an osmotic gradient through the frog urinary bladder wall. Spironolactone (0.1), and hydrochlorothiazide (5.0) showed only a weak action on osmotic permeability. MercusalR, clopamide and triamterene did not affect water transport. 2. The presence of 0.2--1.0 mU/ml vasopressin (ADH) after pretreatment with a diuretic did not result in summation of the effects of both drugs used. 0.01--0.1 mM ethacrynic acid and 0.01 mM MercusalR significantly decreased the reaction to ADH. 1.0 mM furosemide, 0.1 mM spironolactone, 0.01 mM clopamide and 0.8 mM acetazolamide did not change the reaction to ADH. A reduction in the cellular response to ADH and a decrease in the osmotic permeability of the tubular wall may be responsible in part for the diuretic action of ethacrynic acid and MercusalR.

MeSH
diuretika farmakologie MeSH
lékové interakce MeSH
močový měchýř účinky léků metabolismus MeSH
permeabilita MeSH
Rana temporaria MeSH
techniky in vitro MeSH
vasopresiny farmakologie MeSH
voda metabolismus MeSH
žáby MeSH
zvířata MeSH
Check Tag
zvířata MeSH
Publikační typ
časopisecké články MeSH
Názvy látek
diuretika MeSH
vasopresiny MeSH
voda MeSH

Článek

Milníky kardiovaskulární terapie. V. Diuretika
[Milestones of cardiovascular therapy. V. Diuretics]

After their introduction in 1959, thiazide diuretics have become the cornerstone in the managment of ...

Jerie, P
Autor Jerie, P

Casopis lekaru ceskych. 2007 ; 146 (11) : 858-62.

Cas Lek Cesk
ISSN 0008-7335
Zdroj

After their introduction in 1959, thiazide diuretics have become the cornerstone in the managment of heart failure and hypertension. They prevent sodium reabsorption in the upper segment of the distal tubule, increase the diuresis and, by diminishing the intravascular volume, they reduce the preload. With vigorous diuresis, cardiac output may drop under the critical level, and hypovolaemia, hypotension, syncopes and dehydratation with severe water-mineral disturbance may occur. A similar disorder takes place after aggressive administration of loop diuretics which act by the same mechanism at the ascending limb of the loop of Henle. Moreover, any chronic treatment with saluretics triggers the contraregulatory activation of RAAS. Thus, the dosing should be cautiously titrated, and with diminishing efficacy the diuretic is to be replaced by another one, or a second drug is to be added. With any potent diuretic agent, electrolyte depletion may occur; therefore, minimal active doses should be applied, potassium-sparing diuretics added or a pause should be inserted after/before furosemide with spirolactone. Hyponatraemia and hypokalaemia are common, and in combined treatment with ACE-inhibitors and spirolactone, hyperkalaemia is frequent. With long-term treatment, a rebound period of sodium reabsorption follows, and the diuretic effect is reduced or lost. To overcome this ",diuretic resistance", the dietary sodium is to be restricted, physical effort avoided and salt retaining drugs (NSAIDs and similar) eliminated. In the article, a short review of basic physiology concerning the water-electrolyte balance and the distribution of body-water is summarized.