The authors describe occurence asynchronic tumor triplicity. In the year 1980 in 56 years old patient had histologically proven rectal adenocarcinoma and consequently was done radical Miles amputation of rectum. In December 1991 in the same patient was histologically proven well differentiated adenocarcinoma of prostate after transurethral resection of prostate. Prostate cancer was threated bilateral orchiectomy (March 1992) and consequently from April to June 1992 was done small-volume irradiation of pelvic by Betatron X-ray, box technique with dosage 70 Gy. In November 1992 there was done radical transperitoneal nephrectomy on right side for renal carcinoma. Histologically was proven moderately differentiated clear cell renal carcinoma. In August 1994 was found suspected pulmonary metastases, wich was proof on CT in the January 1995. Therapy was Imodin, Wobenzym, Vinblastin. Patient was died of generalisation renal cancer in the February 1998. The carcinoma of prostate and rectum wasn't found in the autopsy. The authors emphasize pertinence radical surgical access incuding multiplex malignant tumors and consider to carry out oncology screening in the all of patients with proven malignant tumor.

• MeSH
• adenokarcinom * chirurgie   MeSH
• karcinom z renálních buněk * chirurgie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory ledvin * chirurgie   MeSH
• nádory prostaty * chirurgie   MeSH
• nádory rekta * chirurgie   MeSH
• sekundární malignity * chirurgie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

Xanthogranulomatous pyelonephritis is a chronic inflammatory disease of the kidney characterized by destruction and replacement of the renal parenchyma with granulomatous tissue containing lipid-filled macrophages. The disease affects mainly elders, more frequent females and is difficult to differentiate it from renal neoplasms by standard diagnostic imaging methods. This case report confirms it.

• MeSH
• diferenciální diagnóza MeSH
• dospělí MeSH
• karcinom z renálních buněk diagnóza   patologie   MeSH
• ledviny patologie   MeSH
• lidé MeSH
• nádory ledvin diagnóza   patologie   MeSH
• xantogranulomatózní pyelonefritida diagnóza   patologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

Incidence of multiple synchronic carcinomas is on rise. It may be attributed to improvements in diagnostic technology and other factors, as well. The authors wish to share their experience in this case review dealing with the synchronic colorectal carcinoma and carcinoma of the left kidney, with literature data added. The causative factors of the multiple tumors should be searched for at subcellural levels. They result from genetic transformations in a particular patient and may also be affected by environmental factors. It must be remembered, that cancer need not affect a single organ system. However, a single organ system may be affected by cancer in several locations, which must be born in mind when a diagnosis is made.

• MeSH
• adenokarcinom * MeSH
• karcinom z renálních buněk * MeSH
• lidé středního věku MeSH
• lidé MeSH
• mnohočetné primární nádory * MeSH
• nádory ledvin * MeSH
• nádory rekta * MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

INTRODUCTION: The frequency of pancreatic metastases ranges from 2% to 5%. Pancreas is an elective site for metastases from renal carcinoma. Pancreatic metastases from renal cell carcinoma are frequently the only metastatic site and they typically occur in the seventh decade of life. CASE REPORT: We report 1 female patient (aged 58 years) with multifocal and isolated pancreatic metastases of renal cell carcinoma. Total duodenopancreatectomy was performed. CONCLUSION: In selected cases, pancreatic resection due to renal cell cancer metastases is deemed indicated, improving overall patient survival. KEY WORDS: renal cell carcinoma (RCC) isolated pancreatic metastases total duodenopancreatectomy.

• MeSH
• karcinom z renálních buněk diagnostické zobrazování   sekundární   chirurgie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory ledvin patologie   MeSH
• nádory slinivky břišní diagnostické zobrazování   sekundární   chirurgie   MeSH
• pankreatoduodenektomie * MeSH
• PET/CT MeSH
• počítačová rentgenová tomografie MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

In the article the authors present the case of a patient with clear cell renal carcinoma, where after nephrectomy local metastases appeared. The treatment of choice was sunitinib. After 20 cycles of therapy heavy hypothyroidism was verified which required substitution by thyroxine. Elevated levels of TSH appeared in up to 70% and hypothyrodism in up to 40% of thus treated patients. Also described is the mechanism of action of sunitinib. There seems to exist a correlation between the "adverse effects" of the drug and a better result of the therapy of cancer, however, prospective studies are absent. Most experts agree that the thyroid function during treatment with sunitinib needs to be monitored.

• MeSH
• hypotyreóza chemicky indukované   MeSH
• indoly škodlivé účinky   terapeutické užití   MeSH
• inhibitory angiogeneze škodlivé účinky   terapeutické užití   MeSH
• karcinom z renálních buněk farmakoterapie   sekundární   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory ledvin farmakoterapie   patologie   MeSH
• protinádorové látky škodlivé účinky   terapeutické užití   MeSH
• pyrroly škodlivé účinky   terapeutické užití   MeSH
• sunitinib MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• indoly MeSH
• inhibitory angiogeneze MeSH
• protinádorové látky MeSH
• pyrroly MeSH
• sunitinib MeSH

There is a new era of treatment options since introduction of new biological targeted therapies (tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors) in renal cell cancer. However, in patients who developed brain metastases, there is still treatment dilemma about an optimal therapeutic scenario, particularly in the subgroup of patients with-out disease progression outside the central nervous system. The objective of this case report is to present that it is possible to continue the same targeted therapy after development of brain metastasis after application of local whole brain irradiation with meaningful overall survival.

• MeSH
• indoly MeSH
• inhibitory enzymů terapeutické užití   MeSH
• karcinom z renálních buněk farmakoterapie   MeSH
• lidé MeSH
• nádory ledvin farmakoterapie   MeSH
• nádory mozku farmakoterapie   sekundární   MeSH
• progrese nemoci MeSH
• protinádorové látky terapeutické užití   MeSH
• pyrroly MeSH
• senioři MeSH
• sirolimus MeSH
• sunitinib MeSH
• TOR serin-threoninkinasy metabolismus   MeSH
• tyrosinkinasy antagonisté a inhibitory   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• indoly MeSH
• inhibitory enzymů MeSH
• protinádorové látky MeSH
• pyrroly MeSH
• sirolimus MeSH
• sunitinib MeSH
• TOR serin-threoninkinasy MeSH
• tyrosinkinasy MeSH