OBJECTIVE: Recent evidence indicates that in psychiatric patients with schizophrenia and depression, lateralized EDA changes linked to temporal-limbic electrophysiological dysfunction occur. These clinical findings provide evidence for brain asymmetry and disruptions related to integrative brain activity in pathological conditions. METHODS: These changes in brain asymmetry may be assessed by linear analysis of EDA measurement and nonlinear analysis of brain complexity calculated as information entropy. Two groups of patients with established diagnosis of paranoid schizophrenia (N=35), unipolar depression (N=35) and a control group of 35 healthy controls were examined by measurement of bilateral electrodermal activity (EDA). In non-linear data analysis of the EDA time series in resting state the method of recurrence quantification analysis was applied. RESULTS: In these patients significant right-left EDA asymmetry and asymmetry of information entropy calculated by non-linear recurrence quantification analysis of EDA records have been found. Similar asymmetry has not been observed in the group of healthy controls. CONCLUSIONS: Because information entropy reflects the complexity of the deterministic structure in the system, then unilaterally increased entropy in patients with schizophrenia and depression likely indicates specific nonlinear disturbances in limbic circuits that modulate EDA. These data are in accordance with recent findings that indicate apparent differences in nonlinear neural patterns in the psychiatric diseases and nonlinear behavior of healthy brain.

• MeSH
• deprese patofyziologie   MeSH
• dospělí MeSH
• elektrofyziologie MeSH
• funkční lateralita fyziologie   MeSH
• galvanická kožní odpověď fyziologie   MeSH
• kůže inervace   patofyziologie   MeSH
• lidé MeSH
• nelineární dynamika MeSH
• schizofrenie patofyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky kontrolované MeSH
• práce podpořená grantem MeSH

OBJECTIVES: Recent evidence indicates frequent EEG abnormalities in dissociated patients. This evidence is in agreement with findings that in certain psychiatric patients, psychosensory symptoms of epileptogenic nature, the so-called complex partial seizure-like symptoms occur. With respect to these findings, a hypothesis examined in this study states that increased level of experienced traumatic stress and dissociation in pathological conditions such as schizophrenia or depression relates to increased score of complex partial seizure-like symptoms. Also is suggested that the complex partial seizure-like symptoms might be related to unilateral hemispheric electrophysiological dysfunction, stress and dissociation. PARTICIPANTS AND METHODS: Psychometric assessment of dissociation, stress and measurement of right-left asymmetry of bilateral EDA in patients with schizophrenia (N=34) and depression (N=41) in comparison to healthy controls (N=36). RESULTS: Results indicate that increased traumatic stress and dissociation in both groups of patients significantly relate to increased level of complex partial seizure-like symptoms, and may cause the right-left EDA asymmetry. CONCLUSIONS: The data suggest relationship between left-hemispheric asymmetry and sympathetic over-activation in schizophrenia, and between right-hemispheric asymmetry with sympathetic under-activation in depression.

• MeSH
• depresivní poruchy komplikace   patofyziologie   MeSH
• disociační poruchy komplikace   patofyziologie   MeSH
• dospělí MeSH
• elektroencefalografie MeSH
• epilepsie komplexní parciální komplikace   patofyziologie   MeSH
• funkční lateralita fyziologie   MeSH
• galvanická kožní odpověď fyziologie   MeSH
• lidé MeSH
• neparametrická statistika MeSH
• psychický stres komplikace   patofyziologie   MeSH
• psychometrie MeSH
• referenční hodnoty MeSH
• schizofrenie komplikace   patofyziologie   MeSH
• studie případů a kontrol MeSH
• sympatický nervový systém patofyziologie   MeSH
• velký mozek patofyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH