Naphyrone, also known as NRG-1, is a novel psychoactive substance (NPS), a cathinone with stimulatory properties available on the grey/illicit drug market for almost a decade. It is structurally related to infamously known powerful stimulants with the pyrovalerone structure, such as alpha-pyrrolidinovalerophenone (α-PVP) or methylenedioxypyrovalerone (MDPV) that are labeled as a cheap replacement for cocaine and other stimulants. Despite the known addictive potential of α-PVP and MDPV, there are no studies directly evaluating naphyrone's addictive potential e.g., in conditioned place preference (CPP) test or using self-administration. Therefore, our study was designed to evaluate the addictive potential in a CPP test in male Wistar rats and compare its effect to another powerful stimulant with a high addictive potential - methamphetamine. Naphyrone increased time spent in the drug-paired compartment with 5 and 20 mg/kg s.c. being significant and 10 mg/kg s.c. reaching the threshold (p = 0.07); the effect was comparable to that of methamphetamine 1.5 mg/kg s.c. The lowest dose, naphyrone 1 mg/kg s.c., had no effect on CPP. Interestingly, no dose response effect was detected. Based on these data, we are able to conclude that naphyrone has an addictive potential and may possess a significant risk to users.

• Klíčová slova
• Addictive potential, CPP, Conditioned place preference test, Naphyrone, Novel psychoactive substances,
• MeSH
• alkaloidy farmakologie   MeSH
• chování zvířat účinky léků   MeSH
• klasické podmiňování účinky léků   MeSH
• krysa rodu Rattus MeSH
• methamfetamin aplikace a dávkování   farmakologie   MeSH
• modely nemocí na zvířatech MeSH
• pentanony aplikace a dávkování   farmakologie   MeSH
• poruchy spojené s užíváním psychoaktivních látek * MeSH
• potkani Wistar MeSH
• pyrrolidiny aplikace a dávkování   farmakologie   MeSH
• stimulanty centrálního nervového systému aplikace a dávkování   farmakologie   MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• 1-naphthalen-2-yl-2-pyrrolidin-1-ylpentan-1-one MeSH Prohlížeč
• alkaloidy MeSH
• cathinone MeSH Prohlížeč
• methamfetamin MeSH
• pentanony MeSH
• pyrrolidiny MeSH
• stimulanty centrálního nervového systému MeSH