Effects of synthetic cathinone naphyrone in the conditioned place preference test - Evidence of its addictive potential
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
34906607
DOI
10.1016/j.bbr.2021.113713
PII: S0166-4328(21)00601-X
Knihovny.cz E-resources
- Keywords
- Addictive potential, CPP, Conditioned place preference test, Naphyrone, Novel psychoactive substances,
- MeSH
- Alkaloids pharmacology MeSH
- Behavior, Animal drug effects MeSH
- Conditioning, Classical drug effects MeSH
- Rats MeSH
- Methamphetamine administration & dosage pharmacology MeSH
- Disease Models, Animal MeSH
- Pentanones administration & dosage pharmacology MeSH
- Substance-Related Disorders * MeSH
- Rats, Wistar MeSH
- Pyrrolidines administration & dosage pharmacology MeSH
- Central Nervous System Stimulants administration & dosage pharmacology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 1-naphthalen-2-yl-2-pyrrolidin-1-ylpentan-1-one MeSH Browser
- Alkaloids MeSH
- cathinone MeSH Browser
- Methamphetamine MeSH
- Pentanones MeSH
- Pyrrolidines MeSH
- Central Nervous System Stimulants MeSH
Naphyrone, also known as NRG-1, is a novel psychoactive substance (NPS), a cathinone with stimulatory properties available on the grey/illicit drug market for almost a decade. It is structurally related to infamously known powerful stimulants with the pyrovalerone structure, such as alpha-pyrrolidinovalerophenone (α-PVP) or methylenedioxypyrovalerone (MDPV) that are labeled as a cheap replacement for cocaine and other stimulants. Despite the known addictive potential of α-PVP and MDPV, there are no studies directly evaluating naphyrone's addictive potential e.g., in conditioned place preference (CPP) test or using self-administration. Therefore, our study was designed to evaluate the addictive potential in a CPP test in male Wistar rats and compare its effect to another powerful stimulant with a high addictive potential - methamphetamine. Naphyrone increased time spent in the drug-paired compartment with 5 and 20 mg/kg s.c. being significant and 10 mg/kg s.c. reaching the threshold (p = 0.07); the effect was comparable to that of methamphetamine 1.5 mg/kg s.c. The lowest dose, naphyrone 1 mg/kg s.c., had no effect on CPP. Interestingly, no dose response effect was detected. Based on these data, we are able to conclude that naphyrone has an addictive potential and may possess a significant risk to users.
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