The influence of diabetes mellitus, streptozotocin-induced diabetes and ageing on the non-enzymatic glycosylation of myosin from cardiac and skeletal muscles was investigated. In cardiac muscle, and to a lesser extent also in skeletal muscles of the rat, non-enzymatic glycosylation of myosin increases with the age, as measured in 6-, 12- and 29-month-old animals. Skeletal muscle myosin from diabetic humans and also that from diabetic rat cardiac muscle are more glycosylated when compared with control myosin preparations. Ca(2+)-ATPase activity of myosin is lower in muscles of diabetic individuals as compared with control muscles.

• MeSH
• Ca2+-ATPasy metabolismus   MeSH
• diabetes mellitus metabolismus   MeSH
• experimentální diabetes mellitus metabolismus   MeSH
• glykosylace MeSH
• krysa rodu Rattus MeSH
• lidé MeSH
• myokard metabolismus   MeSH
• myosiny analýza   metabolismus   MeSH
• senioři MeSH
• srdce růst a vývoj   MeSH
• stárnutí metabolismus   MeSH
• svaly metabolismus   MeSH
• vývoj svalů MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• lidé MeSH
• senioři MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• Ca2+-ATPasy MeSH
• myosiny MeSH