The authors present a review on the effects of obesity on male fertility. Current scientific findings suggest an elevated risk of infertility among couples in which the male partner is obese. In obese men can be found reduced serum levels of androgens and SHBG and increased estrogen levels without compensatory increase in FSH. Among other impacts of male obesity that may contribute to increased risk of infertility are altered retention and metabolism of environmental toxins, lifestyle, sexual dysfunction, genetic factors, excessive secretion of hormones derived from adipose tissue, oxidative stress, sperm specific proteomic changes or elevated levels of cytokines. The increasing prevalence of obesity calls for greater clinical awareness of its impact on male fertility.

• MeSH
• lidé MeSH
• mužská infertilita etiologie   MeSH
• obezita komplikace   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• přehledy MeSH

OBJECTIVE: Description of the relationship between the overweight man and the reduction of his reproductive potential. DESIGN: Review article. SETTING: Center of Assisted Reproduction Sanus, Jihlava. METHODS: Approximately 15% of couples are trying to get pregnant unsuccessfully. In order to better assess the possible causes of this failure, it is vital to take into consideration the influence of owerweight and/or obesity in both men and women. Reduction of the reproductive potential of obese men occurs due to changes in hormonal levels regulating spermatogenesis, increased temperatures in the testicles, environmental toxins accumulated in adipose tissue, increased levels of oxidative stress as well as a higher incidence of erectile dysfunction. The likelihood of pregnancy is reduced even in the case of assisted reproduction methods. CONCLUSION: Obesity or overweight causes reduced fertility of men and often significantly prolongs the time required to achieve pregnancy. Prior to applying treatment for infertility, we assess all possibilities to increase the reproductive potential of overweight men. Significant weight loss in obese men results in regulated hormonal levels, moreover, in most cases, this leads to improved spermiogram parameters with increasing chances of getting pregnant.

• Klíčová slova
• body mass index, infertility, infertility spermiogram., male obesity, spermiogram,
• MeSH
• erektilní dysfunkce komplikace   patofyziologie   MeSH
• hmotnostní úbytek MeSH
• lidé MeSH
• mužská infertilita krev   etiologie   MeSH
• nadváha krev   komplikace   MeSH
• obezita krev   komplikace   MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Obesity can adversely affect human health, including fertility. While obesity can disturb the hormonal profile of the female organism and is associated with fertility loss, little is known about what effect male obesity has on fertility. The present study analysed sperm samples of 153 donors. The men were selected from couples attending an infertility clinic, who had tried for 12 months or more to achieve pregnancy without success. The age of the men under investigation was recorded, and their body mass index (BMI) was calculated. All semen samples were assessed for volume, concentration, motility and morphology. Sperm chromatin integrity was measured by sperm chromatin structure assay. Quality of sperm chromatin condensation was assessed by toluidine blue, aniline blue and chromomycin A3 staining. We can conclude that the impact of elevated BMI on the parameters investigated (basic semen parameters, chromatin integrity and chromatin condensation) was not proven in this study. On the other hand, ejaculate quality appeared to be affected by ageing. The impact was reflected by chromatin integrity, which is a factor that can substantially affect fertility in men, rather than by basic sperm parameters.

• MeSH
• analýza spermatu * MeSH
• chromatin genetika   MeSH
• dospělí MeSH
• fragmentace DNA MeSH
• index tělesné hmotnosti MeSH
• lidé středního věku MeSH
• lidé MeSH
• motilita spermií MeSH
• mužská infertilita etiologie   MeSH
• obezita komplikace   MeSH
• počet spermií MeSH
• sperma MeSH
• spermie cytologie   MeSH
• stárnutí * MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• chromatin MeSH