A quantitative description of motor seizures induced by pentylenetetrazol (PTZ, metrazol) was performed. Seizures were induced by PTZ in doses from 40 to 120 mg/kg s.c. in 477 male albino rats of the Wistar strain 7 to 90 days old. Two patterns of seizures were elicited: minimal, i.e. predominantly clonic seizures of facial and forelimb muscles with preserved righting ability, and major, i.e. generalized tonic-clonic seizures with a loss of righting reflex. Minimal seizures could be reliably elicited since the age of 18 days; the CD50 for these seizures did not significantly differ with age. Major seizures were elicited regularly at all developmental stages studied. Their CD50 did not significantly differ among 7-, 12- and 25-day-old rat pups but the value for 18-day-old rats was smaller and for adult animals larger than these three age groups.

• MeSH
• epilepsie tonicko-klonická chemicky indukované   patofyziologie   MeSH
• injekce subkutánní MeSH
• krysa rodu Rattus MeSH
• pentylentetrazol * MeSH
• potkani Wistar MeSH
• stárnutí fyziologie   MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• záchvaty chemicky indukované   patofyziologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• pentylentetrazol * MeSH

The influence of flumazenil on seizures induced by pentylenetetrazol (PTZ) was studied in rats aged 7, 12, 18, 25, and 90 days. Flumazenil in doses of 25, 37.5, and 50 mg/kg IP injected 10 min before PTZ exhibited a dose-dependent anticonvulsant action in all age groups studied. It was more effective against generalized tonic-clonic than against minimal clonic seizures at all developmental stages studied. In the two youngest groups, minimal seizures were elicited only rarely under control conditions. Pretreatment with the two lower doses of flumazenil resulted in an increased incidence of this type of seizure for these two groups. The anticonvulsant activity found in all age groups is in agreement with data from other benzodiazepines and speaks against a pure benzodiazepine-antagonistic action of flumazenil.

• MeSH
• antikonvulziva farmakologie   MeSH
• epilepsie tonicko-klonická chemicky indukované   prevence a kontrola   MeSH
• flumazenil farmakologie   MeSH
• krysa rodu Rattus MeSH
• pentylentetrazol MeSH
• potkani Wistar MeSH
• stárnutí fyziologie   MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• záchvaty chemicky indukované   prevence a kontrola   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antikonvulziva MeSH
• flumazenil MeSH
• pentylentetrazol MeSH