Ghrelin was originally isolated from the rat stomach and significant amounts were found also in the kidney. Present study was designed to examine changes in ghrelin levels in renal failure and their relationship to the GH/IGF-I axis. Fourty patients with mild-to-severe CRF (19 men, 21 women, aged 62.5 +/- 2.2 years, BMI 27.57 +/- 0.73 kg/m(2)) and 34 healthy control subjects (17 men, 17 women, aged 60 +/- 2.6 years, BMI 27.55 +/- 0.79 kg/m(2)) were included in the study. Total ghrelin levels were significantly increased in patients with chronic renal failure (CRF) (p < 0.0001). Total ghrelin in CRF correlated positively with active ghrelin (p < 0.001), GH (p < 0.05), IGF-I (p < 0.05), free IGF-I (p = 0.0001), IGFBP-3 (p < 0.01), IGFBP-2 and -6 (p < 0.05). Active ghrelin in CRF correlated positively with IGF-I (p < 0.001), free-IGF-I (p < 0.005), IGFBP-2 (p < 0.05) and IGFBP-3 (p < 0.05). However, most of the correlation were markedly reduced and the significance disappeared after adjustment for different creatinine levels. Hemodialysis in patients with end stage renal disease (ESRD) resulted in a significant reduction of plasma total and active ghrelin (p < 0.01 and p < 0.001 respectively). In conclusion we demonstrated elevated plasma levels of total ghrelin in CRF, and a reduction of total and active ghrelin after a single course of hemodialysis in ESRD. The elevation of ghrelin levels could be caused by impaired clearance and/or metabolism of ghrelin in the kidney. We did not prove clearly significant relationship between ghrelin serum levels and parameters of GH/IGF-I axis in study subjects.

• MeSH
• časové faktory MeSH
• chronické selhání ledvin krev   metabolismus   MeSH
• dialýza ledvin MeSH
• ghrelin MeSH
• IGFBP-3 metabolismus   MeSH
• index tělesné hmotnosti MeSH
• insulinu podobný růstový faktor I metabolismus   MeSH
• kreatin krev   MeSH
• ledviny metabolismus   MeSH
• leptinové receptory MeSH
• lidé středního věku MeSH
• lidé MeSH
• peptidové hormony krev   chemie   metabolismus   MeSH
• protein 2 vázající insulinu podobné růstové faktory metabolismus   MeSH
• receptory buněčného povrchu chemie   MeSH
• renální insuficience krev   MeSH
• růstový hormon metabolismus   MeSH
• statistické modely MeSH
• studie případů a kontrol MeSH
• zvířata MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• ghrelin MeSH
• IGFBP-3 MeSH
• insulinu podobný růstový faktor I MeSH
• kreatin MeSH
• leptinové receptory MeSH
• peptidové hormony MeSH
• protein 2 vázající insulinu podobné růstové faktory MeSH
• receptory buněčného povrchu MeSH
• růstový hormon MeSH