- MeSH
- Exocrine Glands * anatomy & histology physiology MeSH
- Humans MeSH
- Prostate physiology MeSH
- Terminology as Topic MeSH
- Urethra * MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- MeSH
- Hormones physiology MeSH
- Prostatic Hyperplasia physiopathology MeSH
- Humans MeSH
- Prostate physiopathology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Hormones MeSH
The authors investigated the proteolytic activity of the normal prostate, the prostate with benign hypertrophy and with cancer. Pepsinogen obtained from the normal prostate was isolated on DEAHP pearl cellulose and purified by means of affinite chromatography. Separation on affinite chromatography and by electrophoresis on agar confirmed that the pepsinogen is identical with gastric progastricsin. The proteolytic activity was examined by a modified method of Anson and Mirsky, and with the aid of synthetic substrates it was assessed quantitatively in all three examined groups. The enzyme activity of the carcinomatous tissue practically did not differ from the activity of the normal prostate. In beniming hypertrophy of the prostate the proteolytic activity assessed by the breakdown of haemoglobin is markedly reduced and when tested on the breakdown of synthetic substrates [For-Tyr-Tyr- and Ac-Phe- Tyr (I2)] it is practically zero.
- MeSH
- Prostatic Hyperplasia metabolism MeSH
- Humans MeSH
- Prostatic Neoplasms analysis MeSH
- Pepsinogens analysis MeSH
- Prostate analysis MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Pepsinogens MeSH
The determination of the nature of heterogeneous foci within the prostate is up till now insufficient. With the help of a standard method using a scanner with a changeable plane of cut and frequency of 7.0 MHz, 292 patients were examined with an enlarged or standard size of prostate and with morphologically proved prostate cancer. A high level of sensitivity and quite a low specification of examinations were found out. To distinguish the kind of heterogeneous foci within the prostate is of decisive importance for the carcinoma diagnostics. In 152 patients, the following characteristics were evaluated: the size, shape and contour of the focus, its localisation, echogenicity and homogeneity of echostructure. 70 patients were examined using a method evaluating the vascularisation of a tumour with CFM and the frequency analysis according to Furier. The results of examinations performed with the help of the above mentioned methods yielded some new experience, however, they did not contribute to the qualitative determination of heterogeneous intracapsular foci within the prostate. Their character can be defined only by punctual or aspirational biopsy.
- MeSH
- Prostatic Hyperplasia diagnosis MeSH
- Humans MeSH
- Prostate pathology MeSH
- Ultrasonography * methods MeSH
- Organ Size MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- MeSH
- Biopsy MeSH
- Prostatic Hyperplasia pathology MeSH
- Biopsy, Needle * MeSH
- Humans MeSH
- Prostatic Neoplasms pathology MeSH
- Prostate pathology MeSH
- Prostatitis pathology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Comparative Study MeSH
At the urological department of the First Surgical Clinic, Faculty of general Medicine Charles University in Prague from January 1977 to December 1986 922 men were operated on account of benign obstruction of the cervix. Ninety-one patients, i.e. 9.8%, with some common signs were subjected to clinical analysis. The criterium for inclusion in the group was the finding of a not enlarged, through on palpation frequently altered prostate, the finding of a histological, endoscopic, X-ray and urodynamic examination. The common sign of these patients was the presence of the disease in young age, a prolonged persistence (up to 20 years) and the frequent presence of supravesical congestion, sometimes with a diverticulum of the urinary bladder. The cause of the disease was dyssynergy, urethrovesical hypertrophy of the poesterior commissure, atrophy of the prostate, subtrigonal hyperplasia of the prostate and a secondary contracture. A transurethral operation was performed in 64 patients, a transvesicalar one in 24 and in three a XY plastic operation was made.
- MeSH
- Prostatic Hyperplasia complications pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Urinary Bladder Neck Obstruction complications surgery MeSH
- Prostate pathology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
The authors evaluated in 13 patients the peroperative and postoperative effect of thermotherapy by transrectal ultrasonography. In all patients for a period of 60 minutes by means of a transurethral cooled catheter a temperature of 50 degrees C was applied. In the two-dimensional B picture in all patients a hypoechogenic border round the urethra was observed which gradually became defined as a canal of varying width. Changes in the blood supply of the prostate were not detected by the authors. The functional equivalent of these changes was an improved uroflowmertric finding and IPPS score.
- MeSH
- Prostatic Hyperplasia diagnostic imaging physiopathology therapy MeSH
- Hyperthermia, Induced * MeSH
- Humans MeSH
- Prostate diagnostic imaging MeSH
- Ultrasonography MeSH
- Urodynamics MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
The technology of fine-needle aspiration of prostatic tissue was described and its results discussed in a group of 45 patients. Demonstration of findings included: normal cytology, adenomyomatous hyperplasia with mosaic pattern of epithelial cells, acute purulent inflammation, chronic inflammation with pseudoxanthomatous lipophages , seminal vesicles with atypical non-cohesive epithelial cells, and neoplasia.
- MeSH
- Adult MeSH
- Prostatic Hyperplasia diagnosis MeSH
- Biopsy, Needle * MeSH
- Middle Aged MeSH
- Humans MeSH
- Prostatic Neoplasms diagnosis MeSH
- Prostate pathology MeSH
- Prostatitis diagnosis MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
Lower urinary tract symptoms (LUTS) are a common condition in older men. The objective of the present study was to evaluate the efficacy and tolerability of cranberry (Vaccinium macrocarpon) powder in men at risk of prostate disease with LUTS, elevated prostate-specific antigen (PSA), negative prostate biopsy and clinically confirmed chronic non-bacterial prostatitis. Forty-two participants received either 1500 mg of the dried powdered cranberries per d for 6 months (cranberry group; n 21) or no cranberry treatment (control group; n 21). Physical examination, International Prostate Symptom Score, quality of life (QoL), five-item version of the International Index of Erectile Function (IIEF-5), basic clinical chemistry parameters, haematology, Se, testosterone, PSA (free and total), C-reactive protein (CRP), antioxidant status, transrectal ultrasound prostate volume, urinary flow rate, ultrasound-estimated post-void residual urine volume at baseline, and at 3 and 6 months, and urine ex vivo anti-adherence activity were determined in all subjects. In contrast to the control group, patients in the cranberry group had statistically significant improvement in International Prostate Symptom Score, QoL, urination parameters including voiding parameters (rate of urine flow, average flow, total volume and post-void residual urine volume), and lower total PSA level on day 180 of the study. There was no influence on blood testosterone or serum CRP levels. There was no statistically significant improvement in the control group. The results of the present trial are the first firm evidence that cranberries may ameliorate LUTS, independent of benign prostatic hyperplasia or C-reactive protein level.
- MeSH
- Prostatic Hyperplasia pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Fruit * MeSH
- Urination Disorders diet therapy MeSH
- Powders MeSH
- Prostate MeSH
- Aged MeSH
- Capsules MeSH
- Vaccinium macrocarpon * MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Powders MeSH
- Capsules MeSH
