We examined the renal function in 18 brain dead patients 2-0 h before removing the kidneys and 72 h after their transplantation to the recipient. The kidneys were preserved by simple hypothermia. In brain dead patients we found no demonstrable relationships between PCr and CCr or between Purea and CCr. At this time the Purea and PCr values are not a sufficiently accurate indicator of renal function. We also examined the plasma and urinary concentrations of Na, K, urea and osmotically active substances and calculated their excretion fractions. We found that, prior to removal, the kidneys were in a state of combined osmotic and water diuresis. The osmotic diuresis was chiefly of a non-sodium type and was produced by a mannitol load. Water diuresis was evidently caused by inhibition of ADH output consequent to brain hypoxia. We also investigated the relationship between the CCr values before nephrectomy and in the early posttransplantation phase. We found that there was a relationship between the recipient's CCr values in the early posttransplantation period and donor's CCr/total ischaemic time index. Calculation of this index can be valuable, especially in high risk transplantations.

• MeSH
• dospělí MeSH
• draslík metabolismus   MeSH
• kreatinin metabolismus   MeSH
• ledviny metabolismus   MeSH
• lidé MeSH
• mladiství MeSH
• močovina metabolismus   MeSH
• mozková smrt * MeSH
• nefrektomie * MeSH
• osmolární koncentrace MeSH
• předškolní dítě MeSH
• sodík metabolismus   MeSH
• transplantace ledvin * MeSH
• vyšetření funkce ledvin * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• draslík MeSH
• kreatinin MeSH
• močovina MeSH
• sodík MeSH

BACKGROUND: Hyperchloremia produces renal vasoconstriction and fall in glomerular filtration rate. In 90% of brain-dead organ donors, diabetes insipidus develops, characterized by inappropriate diuresis, hyperosmolality, and hyperchloremia. The aim of this study was to determine the relationship between the serum concentration of chlorides of the donor and the onset of the function of the kidney allograft in the recipient. METHODS: We retrospectively studied 213 donors and kidney allograft recipients. Serum creatinine concentrations and glomerular filtration rates on the 1st, 7th, and 30th days after transplantation of the recipients from hyperchloremic donors were compared with the recipients from normochloremic donors, as well as the incidences of acute tubular necrosis and delayed graft function. RESULTS: On the 1st day, serum creatinine concentrations of the recipients from hyperchloremic and normochloremic donors, respectively, were 448.2 ± 212.1 μmol/L and 502.2 ± 197.8 μmol/L (P = .1), on the 7th day, 168.6 ± 102.6 μmol/L and 196.9 ± 120.6 μmol/L (P = .13), and on the 30th day, 129.4 ± 43.3 μmol/L and 131.8 ± 43.6 μmol/L (P = .73). The differences were statistically significant. The groups also did not differ significantly in glomerular filtration rates and incidences of acute tubular necrosis and delayed graft function. CONCLUSIONS: In this study, no significant correlation between serum chloride concentrations of the organ donors and the onset of the function of kidney allografts in the recipients was found.

• MeSH
• acidóza komplikace   patofyziologie   MeSH
• akutní tubulární nekróza krev   epidemiologie   etiologie   MeSH
• alografty patofyziologie   MeSH
• chloridy krev   fyziologie   MeSH
• dárci tkání * MeSH
• dospělí MeSH
• hodnoty glomerulární filtrace MeSH
• incidence MeSH
• kreatinin krev   MeSH
• ledviny patofyziologie   MeSH
• lidé MeSH
• mozková smrt patofyziologie   MeSH
• opožděný nástup funkce štěpu krev   epidemiologie   etiologie   MeSH
• pooperační komplikace krev   epidemiologie   etiologie   MeSH
• retrospektivní studie MeSH
• transplantace ledvin * MeSH
• vyšetření funkce ledvin MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• chloridy MeSH
• kreatinin MeSH