OBJECTIVES: To investigate the associations of environmental MS risk factors with clinical and MRI measures of progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. METHODS: We analyzed 211 CIS patients (age: 28.9±7.8 years) enrolled in the SET study, a multi-center study of high-risk CIS patients. Pre-treatment samples were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) early nuclear antigen-1 (EBNA-1), viral capsid antigen (VCA), early antigen-diffuse (EA-D), 25 hydroxy-vitamin D3 and cotinine levels and HLA DRB1*1501 status. The inclusion criteria required evaluation within 4 months of the initial demyelinating event, 2 or more brain MRI lesions and the presence of two or more oligoclonal bands in cerebrospinal fluid. All patients were treated with interferon-beta. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months. RESULTS: The time to first relapse decreased and the number of relapses increased with anti-CMV IgG positivity. Smoking was associated with increased number and volume of contrast-enhancing lesions (CEL) during the 2-year period. The cumulative number of CEL and T2 lesions during the 2-year period was greater for individuals in the highest quartile of anti-EBV VCA IgG antibodies. The percent loss of brain volume was increased for those in the highest quartile of with anti-EBV VCA IgG antibodies. CONCLUSIONS: Relapses in CIS patients were associated with CMV positivity whereas anti-EBV VCA positivity was associated with progression on MRI measures, including accumulation of CEL and T2 lesions and development of brain atrophy.

• MeSH
• Cytomegalovirus imunologie   MeSH
• dospělí MeSH
• HLA-DRB1 řetězec genetika   MeSH
• kohortové studie MeSH
• kouření škodlivé účinky   MeSH
• lidé MeSH
• longitudinální studie MeSH
• mladý dospělý MeSH
• progrese nemoci MeSH
• prospektivní studie MeSH
• protilátky virové krev   MeSH
• rizikové faktory MeSH
• roztroušená skleróza etiologie   imunologie   virologie   MeSH
• virus Epsteinův-Barrové - jaderné antigeny imunologie   MeSH
• životní prostředí MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• Názvy látek
• EBV-encoded nuclear antigen 1 MeSH Prohlížeč
• HLA-DRB1 řetězec MeSH
• HLA-DRB1*15:01 antigen MeSH Prohlížeč
• protilátky virové MeSH
• virus Epsteinův-Barrové - jaderné antigeny MeSH

OBJECTIVES: To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. METHODS: High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment serum from 135 high risk patients with CIS (≥ 2 brain MRI lesions and ≥ 2 oligoclonal bands) enrolled in the Observational Study of Early Interferon β-1a Treatment in High Risk Subjects after CIS study (SET study), which prospectively evaluated the effect of intramuscular interferon β-1a treatment following the first demyelinating event. Thyroid stimulating hormone, free thyroxine, 25-hydroxy vitamin D3, active smoking status and body mass index were also obtained. Clinical and MRI assessments were obtained within 4 months of the initial demyelinating event and at 6, 12 and 24 months. RESULTS: The time to first relapse and number of relapses were not associated with any of the lipid profile variables. Higher LDL-C (p=0.006) and TC (p=0.001) levels were associated with increased cumulative number of new T2 lesions over 2 years. Higher free thyroxine levels were associated with lower cumulative number of contrast-enhancing lesions (p=0.008). Higher TC was associated as a trend with lower baseline whole brain volume (p=0.020). Higher high density lipoprotein was associated with higher deseasonalised 1,25-dihydroxy vitamin D3 (p=0.003) levels and a trend was found for deseasonalised 25-hydroxy vitamin D3 (p=0.014). CONCLUSIONS: In early multiple sclerosis, lipid profile variables particularly LDL-C and TC levels are associated with inflammatory MRI activity measures.

• Klíčová slova
• Clinical Neurology, Mri, Multiple Sclerosis, Neurobiology, Neuroradiology,
• MeSH
• adjuvancia imunologická terapeutické užití   MeSH
• časná lékařská intervence MeSH
• cholesterol krev   MeSH
• demyelinizační nemoci krev   farmakoterapie   MeSH
• dospělí MeSH
• HDL-cholesterol krev   MeSH
• index tělesné hmotnosti MeSH
• injekce intramuskulární MeSH
• interferon beta 1a MeSH
• interferon beta terapeutické užití   MeSH
• kalcifediol krev   MeSH
• kohortové studie MeSH
• kouření škodlivé účinky   krev   MeSH
• LDL-cholesterol krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• longitudinální studie MeSH
• magnetická rezonanční tomografie MeSH
• mladý dospělý MeSH
• mozek účinky léků   patologie   MeSH
• prospektivní studie MeSH
• roztroušená skleróza krev   diagnóza   farmakoterapie   MeSH
• thyreotropin krev   MeSH
• thyroxin krev   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, U.S. Gov't, Non-P.H.S. MeSH
• Geografické názvy
• Česká republika MeSH
• Názvy látek
• adjuvancia imunologická MeSH
• cholesterol MeSH
• HDL-cholesterol MeSH
• interferon beta 1a MeSH
• interferon beta MeSH
• kalcifediol MeSH
• LDL-cholesterol MeSH
• thyreotropin MeSH
• thyroxin MeSH