OBJECTIVES: To investigate the associations of environmental MS risk factors with clinical and MRI measures of progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. METHODS: We analyzed 211 CIS patients (age: 28.9±7.8 years) enrolled in the SET study, a multi-center study of high-risk CIS patients. Pre-treatment samples were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) early nuclear antigen-1 (EBNA-1), viral capsid antigen (VCA), early antigen-diffuse (EA-D), 25 hydroxy-vitamin D3 and cotinine levels and HLA DRB1*1501 status. The inclusion criteria required evaluation within 4 months of the initial demyelinating event, 2 or more brain MRI lesions and the presence of two or more oligoclonal bands in cerebrospinal fluid. All patients were treated with interferon-beta. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months. RESULTS: The time to first relapse decreased and the number of relapses increased with anti-CMV IgG positivity. Smoking was associated with increased number and volume of contrast-enhancing lesions (CEL) during the 2-year period. The cumulative number of CEL and T2 lesions during the 2-year period was greater for individuals in the highest quartile of anti-EBV VCA IgG antibodies. The percent loss of brain volume was increased for those in the highest quartile of with anti-EBV VCA IgG antibodies. CONCLUSIONS: Relapses in CIS patients were associated with CMV positivity whereas anti-EBV VCA positivity was associated with progression on MRI measures, including accumulation of CEL and T2 lesions and development of brain atrophy.
- MeSH
- Cytomegalovirus imunologie MeSH
- dospělí MeSH
- HLA-DRB1 řetězec genetika MeSH
- kohortové studie MeSH
- kouření škodlivé účinky MeSH
- lidé MeSH
- longitudinální studie MeSH
- mladý dospělý MeSH
- progrese nemoci MeSH
- prospektivní studie MeSH
- protilátky virové krev MeSH
- rizikové faktory MeSH
- roztroušená skleróza etiologie imunologie virologie MeSH
- virus Epsteinův-Barrové - jaderné antigeny imunologie MeSH
- životní prostředí MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Názvy látek
- EBV-encoded nuclear antigen 1 MeSH Prohlížeč
- HLA-DRB1 řetězec MeSH
- HLA-DRB1*15:01 antigen MeSH Prohlížeč
- protilátky virové MeSH
- virus Epsteinův-Barrové - jaderné antigeny MeSH
