Heparin inhibits transport of electrons from reduced cytochrome c to cytochrome c oxidase. The effect is due to the interaction of heparin with cytochrome c. It has been observed that binding of heparin to the reduced or oxidized cytochrome c changes the spectrum of cytochrome c at the Soret region. Affinity chromatography of heparin in cytochrome c immobilized to thiol-Sepharose shows that commercial heparin is eluted in the low-affinity and high-affinity fractions. Both participate in the interaction with cytochrome c. Polylysine induces decay of the cytochrome c-heparin complex.

• MeSH
• chromatografie afinitní MeSH
• cytochromy skupiny c chemie   metabolismus   MeSH
• enzymy imobilizované MeSH
• heparin metabolismus   MeSH
• oxidace-redukce MeSH
• polylysin farmakologie   MeSH
• respirační komplex IV antagonisté a inhibitory   metabolismus   MeSH
• spektrální analýza MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• cytochromy skupiny c MeSH
• enzymy imobilizované MeSH
• heparin MeSH
• polylysin MeSH
• respirační komplex IV MeSH