Bordetellae, pathogenic to mammals, produce an immunomodulatory adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) that enables them to overcome the innate immune defense of the host. CyaA subverts host phagocytic cells by an orchestrated action of its functional domains, where an extremely catalytically active adenylyl cyclase enzyme is delivered into phagocyte cytosol by a pore-forming repeat-in-toxin (RTX) cytolysin moiety. By targeting sentinel cells expressing the complement receptor 3, known as the CD11b/CD18 (αMβ₂) integrin, CyaA compromises the bactericidal functions of host phagocytes and supports infection of host airways by Bordetellae. Here, we review the state of knowledge on structural and functional aspects of CyaA toxin action, placing particular emphasis on signaling mechanisms by which the toxin-produced 3',5'-cyclic adenosine monophosphate (cAMP) subverts the physiology of phagocytic cells.

• Klíčová slova
• Bordetella, CD11b/CD18, adenylate cyclase toxin, cAMP, cell signaling, complement receptor 3, innate immunity, membrane pores, repeats-in-toxin, β2 integrins,
• MeSH
• adenylátcyklasový toxin chemie   MeSH
• alveolární makrofágy cytologie   MeSH
• AMP cyklický chemie   MeSH
• Bordetella pertussis MeSH
• dendritické buňky cytologie   MeSH
• fagocyty chemie   MeSH
• kinasa Syk MeSH
• lidé MeSH
• makrofágový antigen 1 MeSH
• neutrofily cytologie   MeSH
• proteinové domény MeSH
• signální transdukce * MeSH
• terciární struktura proteinů MeSH
• vztahy mezi strukturou a aktivitou MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• adenylátcyklasový toxin MeSH
• AMP cyklický MeSH
• kinasa Syk MeSH
• makrofágový antigen 1 MeSH
• SYK protein, human MeSH Prohlížeč