N-Deacetylcolchiceine (DAC) administered i.p. to rats decreased the level of serum cholesterol and apoB. It was accompanied by the fall of HDL-C due to the decrease of both HDL subfractions HDLa and HDLb, and by a rather weaker decrease of LDL-C. The levels of serum and lipoprotein triacylglycerols were not significantly affected. The "clearing reaction" to heparin in DAC rats differed from controls with regard to plasma cholesterol resulting in its accumulation in HDLa and LDL simultaneously with an increased activity of post-heparin lipoprotein lipase. These results suggest that the DAC accelerates the lipoprotein cholesterol metabolism.

• MeSH
• heparin farmakologie   MeSH
• inbrední kmeny potkanů MeSH
• kolchicin analogy a deriváty   farmakologie   MeSH
• krysa rodu Rattus MeSH
• lipoproteiny krev   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• heparin MeSH
• kolchicin MeSH
• lipoproteiny MeSH
• trimethylcolchicinic acid methyl ether MeSH Prohlížeč