• Klíčová slova
• URINATION DISORDERS/therapy *,
• MeSH
• inkontinence moči * MeSH
• lidé MeSH
• poruchy močení terapie   MeSH
• urologické chirurgické výkony * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• hladké svalstvo patofyziologie   MeSH
• inkontinence moči diagnóza   patofyziologie   MeSH
• lidé MeSH
• metody MeSH
• močový měchýř patofyziologie   MeSH
• svalová kontrakce MeSH
• tlak MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• inkontinence moči diagnóza   patofyziologie   MeSH
• lidé MeSH
• manometrie metody   MeSH
• močový měchýř patofyziologie   MeSH
• tlak MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• srovnávací studie MeSH

In a prospective study comprising 29 patients the authors analyzed comprehensively subjective complaints of prostatism using the score of prostatic symptoms (PSS) with the objective urodynamic finding (uroflowmetry, cystometry, pressure flow measurement) in men with benign prostatic hyperplasia. The Boyarsky and Madsen-Iversen PSS did not correlate with the infravesical obstruction assessed by the pressure flow measurements. An obstruction was detected in 23 patients (79.3%), incl. a marginal one in 6 patients (20.7%), the diagnostic sensitivity of free uroflowmetry being 90.9%. Cystometry did not reveal a significant difference between the group with and without an obstruction, instability of the detrusor was found in 12 patients (41.4%) with a significant difference of the maximal cystometric capacity, as compared with the group of patients with a stable detrusor.

• MeSH
• hyperplazie prostaty komplikace   diagnóza   MeSH
• lidé středního věku MeSH
• lidé MeSH
• obstrukce hrdla močového měchýře diagnóza   etiologie   MeSH
• prospektivní studie MeSH
• urodynamika * MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

AIMS: To investigate the effect on urodynamics of 4 weeks treatment with solifenacin succinate in patients with neurogenic detrusor overactivity (NDO) due to multiple sclerosis (MS) or spinal cord injury (SCI). METHODS: SONIC was a prospective, multicenter, double-blind, phase 3b/4 study investigating the efficacy and safety of solifenacin 10 mg in patients with NDO due to MS or SCI. Patients (n = 189) were randomized to placebo or active treatment (solifenacin 5 mg, 10 mg or oxybutynin hydrochloride 15 mg) for 4 weeks, after a 2-week, single-blind, placebo run-in period. The primary endpoint was change in maximum cystometric capacity (MCC) from baseline to end of treatment. The primary analysis compared solifenacin 10 mg versus placebo; all other comparisons were considered secondary. Secondary endpoints included changes in urodynamic parameters, patient-reported outcomes, and safety assessments. RESULTS: In the primary analysis, solifenacin 10 mg significantly improved mean change from baseline MCC versus placebo (P < 0.001) and was associated with improvements in bladder volume at first contraction and at first leak as well as detrusor pressure at first leak. Similar results were obtained for oxybutynin versus placebo. Patient perception of bladder condition significantly improved with solifenacin 10 mg versus placebo (P = 0.041). There was a clear improvement in quality of life (QoL) in the solifenacin arms versus placebo. The overall incidence of adverse events was low. CONCLUSIONS: In patients with NDO due to MS and SCI, 4 weeks of treatment with solifenacin 10 mg improved urodynamic variables and QoL versus placebo and was well tolerated. Neurourol. Urodynam. 36:414-421, 2017. © 2015 Wiley Periodicals, Inc.

• Klíčová slova
• SONIC, cystometry, incontinence quality-of-life (I-QoL), multiple sclerosis (MS), neurogenic detrusor overactivity (NDO), solifenacin, spinal cord injury (SCI), urodynamic,
• MeSH
• dospělí MeSH
• dvojitá slepá metoda MeSH
• hyperaktivní močový měchýř farmakoterapie   patofyziologie   MeSH
• kvalita života MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• neurogenní močový měchýř farmakoterapie   patofyziologie   MeSH
• senioři MeSH
• solifenacin sukcinát aplikace a dávkování   škodlivé účinky   terapeutické užití   MeSH
• urodynamika účinky léků   fyziologie   MeSH
• urologické látky aplikace a dávkování   škodlivé účinky   terapeutické užití   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• randomizované kontrolované studie MeSH
• Názvy látek
• solifenacin sukcinát MeSH
• urologické látky MeSH

UNLABELLED: The Burch procedure has enjoyed in the last decade a favourable status among open surgical repairs for stress urinary incontinence. In the last few years this technique was adapted for endoscopic application. This results in decreased recovery time and diminished postoperative patients discomfort. This endoscopic procedure was further simplified by means of extraperitoneal approach and through the use of Mesh & Tacker technique. This enables a high quality durable colposuspension in significantly shortened operational time. OBJECTIVE: Evaluation of preliminary results and experiences of the above-mentioned new laparoscopic extraperitoneal approach in the treatment of stress incontinence. SETTING: Department of Gynaecology and minimally invasive surgery Na Homolce Hospital. DESIGN: Prospective pilot study. METHODS: The patients with stress incontinence proven clinically and by means of urodynamic investigation (cystometry, stress profilometry and uroflowmetry) were included in the study. The Retzius space was dissected laparoscopically via preperitoneal distention balloon (PDB, Origin Medsystems). Colpofixation to Coopers ligaments was achieved by means of Mesh & Tacker technique, e.g. polypropylen Mesh and aplicator of helicose spirals (Origin Medsystems). RESULTS: In this pilot study of initial 8 patients we may conclude that the above-mentioned method is promising. Of note is shortened operational time (35 min), easy performance without necessity of laparoscopic endosuturing and minimal tissue damage. The small amount of patients and short follow up period would not allow definite conclusions but all the patients are sofar fully continent.

• MeSH
• chirurgická technika pomocí přístrojů a svorek * MeSH
• chirurgické síťky * MeSH
• dospělí MeSH
• laparoskopie * MeSH
• lidé středního věku MeSH
• lidé MeSH
• pilotní projekty MeSH
• stresová inkontinence moči chirurgie   MeSH
• urogenitální chirurgické výkony metody   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

PURPOSE: This work investigated the effects of diuresis, duration of dialysis and age on lower urinary tract function in urologically healthy males on the waiting list for kidney transplant. MATERIALS AND METHODS: The study included all men who had kidney transplants at our centre between January 2009 and December 2014 who had normal urological findings prior to inclusion on the list. Diuresis, the duration of haemodialysis, age, and parameters of function of the lower urinary tract as determined by filling and voiding cystometry were evaluated. RESULTS: The study included 127 men (median age, 59 years; median diuresis, 250 mL; median duration of dialysis, 469.5 days). We found that greater diuresis was accompanied by significantly higher FDV, FDV/Cmax, NDV,Cmax and compliance and by significantly lower Pdet.max, PdetQmax and BOOI. Longer duration of dialysis was accompanied by significantly lower FDV, NDV and Cmax, compliance and Qmax.p and with significantlyhigher Pdet.max, PdetQmax and BOOI. Older age was associated with significantly higher Pdet.max and with significantly lower compliance. Worsening of the basic parameters of the storage function of the lower urinary tract occurred when diuresis decreased to 500-750 mL, when the duration of dialysis was one year and when patients were older than 54 years. CONCLUSION: In healthy male patients on the waiting list for kidney transplant, there were connections between the occurrence of dysfunctions of the lower urinary tract and diuresis, duration of dialysis and age. Patients should be monitored for dysfunctions of the lower urinary tract before and after transplantation.

• MeSH
• časové faktory MeSH
• chronická renální insuficience patofyziologie   terapie   MeSH
• dialýza ledvin * MeSH
• diuréza * MeSH
• hladké svalstvo patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• moč MeSH
• močení MeSH
• močový měchýř patofyziologie   MeSH
• plocha pod křivkou MeSH
• poddajnost MeSH
• ROC křivka MeSH
• senioři MeSH
• seznamy čekatelů MeSH
• svalová kontrakce MeSH
• transplantace ledvin MeSH
• urodynamika * MeSH
• věkové faktory MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH

PURPOSE OF THE STUDY: To present the results of a three-year study on micturition, defecation, gynecological and sexual disorders in middle-aged women who sustained pelvic fractures. MATERIAL AND METHODS: A group of 33 female patients who were treated for unstable pelvic fractures (AO types B or C) in the 2004-2009 period were evaluated (treated group) and compared with 31 women who had given vaginal birth at least once and went to see a urologist because of urinary problems in the period from 2009 to 2010 (control group). The questionnaires used in the study included ICIQ, UIQ, UDI and PISQ12 instruments. Urodynamic tests included flow cystometry, urethral pressure profile at rest and under stress and uroflowmetry. For a comparison of continuous variables of normal distribution, the t-test for independent samples was used. In the questionnaire study when responses were classified as nominal-ordinal variables, the Mann-Whitney U-test was used. Differences between the two patient groups in qualitative variables were tested by Pearson s 2 test. When the expected number of answers in contingency table was lower than 5, Fisher s exact test was used; when the number of answers was 0, Haldane s correction was employed. The results in all tests were considered significant when the level of significance was lower than 5%, i.e. p-value < 0.05. RESULTS: The age of patients in the treated group ranged from 17 to 55 years (average, 32 years), the age in the control group was between 30 and 78 years (average, 58 years). The difference was significant (p<0.001). The control group patients had significantly more serious urination disorders than the treated group patients. Some micturition problems were reported by 25 patients (75%) of the treated group and by all patients of the control group (p<0.001). Intestinal disorders were more frequent in the treated group, in which 19 (61%) patients reported problems as against seven (21%) in the control group. Gynaecological problems involving feelings of genital prolapse had 13 (39%) control patients (p = 0.041). Sexual disorders were markedly worse in the treated group, with 16 (52%) of the patients having problems in comparison with only seven (21%) in the control group. DISCUSSION: A comparison of patient groups composed using the method described here is disputable. The first difficulty lay with a low compliance of the treated patients, of whom only 33 underwent examination out of 52 originally enrolled. The other problem was the necessity of having an exactly defined control group of patients willing to undergo urological and gynaecological examination including urodynamic testing. The groups composed by our method were comparable only in the micturition disorder characteristic. A significantly higher age of the control group affected the comparison of defecation, gynaecological and sexual problems. CONCLUSIONS: The results of this study showed a high occurrence of micturition, defecation and sexual disorders in middle-aged women after pelvic injury. However, the problems are usually not serious enough to make the patients seek help of a specialist. The authors recommend that these problems should be looked for by disorder-directed inquiry in the final period of pelvic fracture treatment and help of a specialist in urology, gynaecology, sexuology or proctology should be offered to the patients in whom disorders have been identified. Key words: urinary incontinence, voiding dysfunction, stool incontinence, obstipation, unstable pelvic fracture.

• MeSH
• defekace * MeSH
• dospělí MeSH
• fraktury kostí komplikace   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• pánevní kosti zranění   MeSH
• poruchy močení etiologie   MeSH
• senioři MeSH
• sexuální dysfunkce fyziologická etiologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• srovnávací studie MeSH