• Klíčová slova
• GERIATRICS *, PANCREATIC NEOPLASMS *, PANCREATITIS *,
• MeSH
• chronická pankreatitida * MeSH
• geriatrie * MeSH
• lidé MeSH
• nádory slinivky břišní * MeSH
• pankreatitida * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• akutní nemoc MeSH
• aprotinin terapeutické užití   MeSH
• atropin terapeutické užití   MeSH
• chlortetracyklin terapeutické užití   MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• pankreatitida * farmakoterapie   chirurgie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• aprotinin MeSH
• atropin MeSH
• chlortetracyklin MeSH

This is an overview of relation between acute and chronic pancreatitis and between acute pancreatitis and pancreatic cancer. Acute pancreatitis and recurrent acute pancreatitis are an etiological factor of chronic pancreatitis. Population-based studies have calculated the risk of acute recurrent pancreatitis after the first attack of acute pancreatitis to be 20% and development of chronic pancreatitis after first attack of acute pancreatitis is 10%. An important risk factor is tobacco smoking. Acute and chronic pancreatitis are risk factors for pancreatic cancer. The risk of acute pancreatitis is related to the number of recurrences of acute pancreatitis, but not the etiology of acute pancreatitis. Acute pancreatitis, as well as chronic pancreatitis, are risk factors for pancreatic cancer. After an attack of acute pancreatitis or recurrent acute pancreatitis a patient should be regarded as a high risk.

• Klíčová slova
• acute pancreatitis, alcohol, chronic pancreatitis, etiology, pancreatic cancer, pancreatic cancer localisation,
• MeSH
• akutní nemoc MeSH
• chronická pankreatitida * komplikace   etiologie   MeSH
• kouření škodlivé účinky   MeSH
• lidé MeSH
• nádory slinivky břišní * etiologie   komplikace   MeSH
• pankreatitida * etiologie   komplikace   MeSH
• recidiva MeSH
• rizikové faktory MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

• Klíčová slova
• PANCREATITIS *,
• MeSH
• chronická pankreatitida * MeSH
• lidé MeSH
• pankreatitida * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Autoimmune pancreatitis is a rare form of chronic pancreatitis. The first descriptions of the disease date back to the 1990s. Etiology is multifactorial, with the use of genetic, environmental and complex immunological mechanisms. It is classified into two subtypes. Type 1 is part of a group of diseases called IgG4-related disease. Clinically is autoimmune pancreatitis manifested by icterus and abdominal discomfort. It can rarely present as acute pancreatitis. There is also a completely asymptomatic form of the disease. The diagnosis is based on abnormalities in histology, imaging methods, serology, the involvement of other organs in relation to IgG4-related disease, and a significant positive response to corticosteroid therapy. Differential diagnosis between the focal form of autoimmune pancreatitis and pancreatic cancer can be complicated, with endosonography playing an important role. In the treatment, we use corticosteroids and other immunosuppressants including biological therapy. Patients with the asymptomatic disease should also be treated to prevent late complications and exocrine and endocrine insufficiency. In addition to drug treatment, endoscopic and/or surgical treatment may be necessary. Even after recovery, the disease can relapse. The relationship between autoimmune pancreatitis and malignancies has not been clearly confirmed. The goal of this review is to provide a comprehensive look at autoimmune pancreatitis and translate latest scientific knowledge into clinical practice.

• Klíčová slova
• Autoimmune pancreatitis, Chronic pancreatitis, IgG4-related disease, Pancreatic cancer, Pancreatic insufficiency,
• MeSH
• akutní nemoc MeSH
• autoimunitní nemoci genetika   imunologie   MeSH
• autoimunitní pankreatitida genetika   imunologie   MeSH
• chronická pankreatitida genetika   imunologie   MeSH
• lidé MeSH
• nádory slinivky břišní genetika   imunologie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

BACKGROUND: Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis that presents clinically with obstructive icterus, histologically with infiltration of pancreatic parenchyma by inflammatory cells leading to chronic inflammation with fibrosis, and therapeutically with good response to corticosteroid therapy. Clinically, it may resemble malignant disease, making diagnosis difficult and requiring a multidisciplinary team (gastroenterologist, endoscopist, radiologist, surgeon, pathologist). Two types of AIP are distinguished. Type 1 is associated with elevated serum immunoglobulin IgG4 and systemic manifestations (IgG4 related diseases). Type 2, without IgG4 elevation, is typically associated with the occurrence of idiopathic inflammatory bowel disease, especially ulcerative colitis. The first line treatment of symptomatic AIP is corticotherapy with an initial dose of 0.6-1 mg/kg/day for the first 2-4 weeks, followed by a gradual de-escalation to prevent frequent relapses. Chronic inflammation, or chronic pancreatitis, is a well-known risk factor for the development of malignancy. The association between carcinogenesis and AIP is widely discussed, but due to the rarity of the disease and a small number of studies, risk estimates vary. Pancreatic carcinoma development is most common in patients with type 1 autoimmune pancreatitis. However, it has been observed that the incidence of extra-pancreatic cancer (stomach, lung, and prostate cancer) is often equal or even higher. It is also considered that AIP may develop from coexisting malignancies as a paraneoplastic syndrome. Screening of patients with AIP for potential carcinogenesis should not be overlooked. PURPOSE: The aim of this review article is to point out a rare (autoimmune) form of chronic pancreatitis with the necessity of follow up with regard to the potential risk of malignancy.

• Klíčová slova
• IgG4 associated disease, IgG4 related diseases, Pancreatic cancer, autoimmune pancreatitis, chronic pancreatitis, pancreatic cancer,
• MeSH
• autoimunitní nemoci komplikace   MeSH
• autoimunitní pankreatitida * komplikace   MeSH
• chronická pankreatitida komplikace   etiologie   MeSH
• lidé MeSH
• nádory slinivky břišní * etiologie   MeSH
• rizikové faktory MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

• MeSH
• akutní nemoc MeSH
• dospělí MeSH
• lidé MeSH
• novorozenec MeSH
• pankreatitida diagnóza   MeSH
• poruchy v puerperiu diagnóza   MeSH
• těhotenství MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Autoimmune pancreatitis is a specific type of chronic pancreatitis. Its clinical manifestation mimics pancreatic cancer. A multidisciplinary approach is necessary to establish the correct diagnosis. Autoimmune pancreatitis can be diagnosed on the basis of symptomatology, imaging methods, endoscopy, serology and histopathological examination. There are two different forms of autoimmune pancreatitis – type 1 and type 2. Type 1 is lymphoplasmacytic sclerosing pancreatitis and type 2 is idiopathic centroductal sclerosing pancreatitis. The disease most often takes a chronic form with acute exacerbations. In this paper we present two case reports of patients operated on for suspected malignancy of the pancreas, who were subsequently diagnosed with autoimmune pancreatitis based on histopathological examination. The aim of this communication is to point out the diagnostic pitfalls of this disease. Surgical treatment is not considered as a standard therapeutic method according to the current guidelines.

• Klíčová slova
• IgG4, autoimmune disease, autoimmune diseases, autoimmune pancreatitis, chronic pancreatitis,
• MeSH
• autoimunitní nemoci * MeSH
• imunoglobulin G MeSH
• lidé MeSH
• pankreatitida * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• imunoglobulin G MeSH

• Klíčová slova
• PANCREATITIS *,
• MeSH
• lidé MeSH
• pankreatitida * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

WHAT IS KNOWN AND OBJECTIVE: Drug-induced acute pancreatitis comprises only 0.5%-2% of all cases of acute pancreatitis. Propofol is a potentially dangerous drug that can cause acute pancreatitis, but this complication is extremely rare. CASE SUMMARY: A 57-year-old patient developed acute pancreatitis after a planned thyroidectomy. As the common causes of acute pancreatitis were excluded, we believe that the pancreatitis was drug-induced, in this case by a single dose of propofol administered to the patient during the surgery. WHAT IS NEW AND CONCLUSION: We present a rare case of propofol-induced acute necrotising pancreatitis, which is to the best of our knowledge the first fatal case reported in an adult patient.

• Klíčová slova
• adverse drug reaction, drug-induced acute pancreatitis, propofol,
• MeSH
• akutní nekrotizující pankreatitida chemicky indukované   MeSH
• anestetika intravenózní aplikace a dávkování   škodlivé účinky   MeSH
• fatální výsledek MeSH
• lidé středního věku MeSH
• lidé MeSH
• propofol aplikace a dávkování   škodlivé účinky   MeSH
• tyreoidektomie metody   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• anestetika intravenózní MeSH
• propofol MeSH