Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Synergistic effect of low K and D vitamin status on arterial stiffness in a general population

O. Mayer, J. Seidlerová, P. Wohlfahrt, J. Filipovský, R. Cífková, V. Černá, A. Kučerová, M. Pešta, R. Fuchsová, O. Topolčan, KMC. Jardon, NEA. Drummen, C. Vermeer,

. 2017 ; 46 (-) : 83-89. [pub] 20170422

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18025038

Grantová podpora
NV15-27109A MZ0 CEP - Centrální evidence projektů

Both vitamins K and D are nutrients with pleiotropic functions in human tissues. The metabolic role of these vitamins overlaps considerably in calcium homeostasis. We analyzed their potential synergetic effect on arterial stiffness. In a cross-sectional study, we analyzed aortic pulse wave velocity (aPWV) in 1023 subjects from the Czech post-MONICA study. Desphospho-uncarboxylated matrix γ-carboxyglutamate protein (dp-ucMGP), a biomarker of vitamin K status, was measured by sandwich ELISA and 25-hydroxyvitamin D3 (25-OH-D3) by a commercial immunochemical assay. In a subsample of 431 subjects without chronic disease or pharmacotherapy, we detected rs2228570 polymorphism for the vitamin D receptor. After adjustment for confounders, aPWV was independently associated with both factors: dp-ucMGP [β-coefficient(S.E.M.)=13.91(4.87); P=.004] and 25-OH-D3 [0.624(0.28); P=.027]. In a further analysis, we divided subjects according to dp-ucMGP and 25-OH-D3 quartiles, resulting in 16 subgroups. The highest aPWV had subjects in the top quartile of dp-ucMGP plus bottom quartile of 25-OH-D3 (i.e., in those with insufficient status of both vitamin K and vitamin D), while the lowest aPVW had subjects in the bottom quartile of dp-ucMGP plus top quartile of 25-OH-D3 [9.8 (SD2.6) versus 6.6 (SD1.6) m/s; P<.0001]. When we compared these extreme groups of vitamin K and D status, the adjusted odds ratio for aPWV≥9.3 m/s was 6.83 (95% CI:1.95-20.9). The aPWV was also significantly higher among subjects bearing the GG genotype of rs2228570, but only in those with a concomitantly poor vitamin K status. In conclusion, we confirmed substantial interaction of insufficient K and D vitamin status in terms of increased aortic stiffness.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18025038
003      
CZ-PrNML
005      
20180718111336.0
007      
ta
008      
180709s2017 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.jnutbio.2017.04.010 $2 doi
035    __
$a (PubMed)28486172
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Mayer, Otto $u 2(nd) Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic; Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic. Electronic address: mayero@fnplzen.cz.
245    10
$a Synergistic effect of low K and D vitamin status on arterial stiffness in a general population / $c O. Mayer, J. Seidlerová, P. Wohlfahrt, J. Filipovský, R. Cífková, V. Černá, A. Kučerová, M. Pešta, R. Fuchsová, O. Topolčan, KMC. Jardon, NEA. Drummen, C. Vermeer,
520    9_
$a Both vitamins K and D are nutrients with pleiotropic functions in human tissues. The metabolic role of these vitamins overlaps considerably in calcium homeostasis. We analyzed their potential synergetic effect on arterial stiffness. In a cross-sectional study, we analyzed aortic pulse wave velocity (aPWV) in 1023 subjects from the Czech post-MONICA study. Desphospho-uncarboxylated matrix γ-carboxyglutamate protein (dp-ucMGP), a biomarker of vitamin K status, was measured by sandwich ELISA and 25-hydroxyvitamin D3 (25-OH-D3) by a commercial immunochemical assay. In a subsample of 431 subjects without chronic disease or pharmacotherapy, we detected rs2228570 polymorphism for the vitamin D receptor. After adjustment for confounders, aPWV was independently associated with both factors: dp-ucMGP [β-coefficient(S.E.M.)=13.91(4.87); P=.004] and 25-OH-D3 [0.624(0.28); P=.027]. In a further analysis, we divided subjects according to dp-ucMGP and 25-OH-D3 quartiles, resulting in 16 subgroups. The highest aPWV had subjects in the top quartile of dp-ucMGP plus bottom quartile of 25-OH-D3 (i.e., in those with insufficient status of both vitamin K and vitamin D), while the lowest aPVW had subjects in the bottom quartile of dp-ucMGP plus top quartile of 25-OH-D3 [9.8 (SD2.6) versus 6.6 (SD1.6) m/s; P<.0001]. When we compared these extreme groups of vitamin K and D status, the adjusted odds ratio for aPWV≥9.3 m/s was 6.83 (95% CI:1.95-20.9). The aPWV was also significantly higher among subjects bearing the GG genotype of rs2228570, but only in those with a concomitantly poor vitamin K status. In conclusion, we confirmed substantial interaction of insufficient K and D vitamin status in terms of increased aortic stiffness.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a kalcifediol $x krev $7 D002112
650    _2
$a proteiny vázající vápník $x metabolismus $7 D002135
650    _2
$a průřezové studie $7 D003430
650    _2
$a extracelulární matrix - proteiny $x metabolismus $7 D016326
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a analýza pulzové vlny $7 D063177
650    _2
$a receptory kalcitriolu $x genetika $7 D018167
650    _2
$a regresní analýza $7 D012044
650    _2
$a tuhost cévní stěny $x fyziologie $7 D059289
650    _2
$a vitamin D $x krev $7 D014807
650    _2
$a vitamin K $x krev $7 D014812
650    _2
$a nedostatek vitaminu K $x patofyziologie $7 D014813
655    _2
$a časopisecké články $7 D016428
700    1_
$a Seidlerová, Jitka $u 2(nd) Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic; Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic.
700    1_
$a Wohlfahrt, Peter $u Centre for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer's Hospital, Prague, Czech Republic; International Clinical Research Centre, St. Anne's University Hospital Brno, Czech Republic.
700    1_
$a Filipovský, Jan $u 2(nd) Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic; Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic.
700    1_
$a Cífková, Renata $u Centre for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer's Hospital, Prague, Czech Republic; International Clinical Research Centre, St. Anne's University Hospital Brno, Czech Republic.
700    1_
$a Černá, Václava $u Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic; Department of Biology, Medical Faculty of Charles University, Pilsen, Czech Republic.
700    1_
$a Kučerová, Alena $u Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic; Department of Biology, Medical Faculty of Charles University, Pilsen, Czech Republic.
700    1_
$a Pešta, Martin $u Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic; Department of Biology, Medical Faculty of Charles University, Pilsen, Czech Republic.
700    1_
$a Fuchsová, Radka $u Department of Immunodiagnostics, University Hospital, Pilsen; Czech Republic.
700    1_
$a Topolčan, Ondřej $u Department of Immunodiagnostics, University Hospital, Pilsen; Czech Republic.
700    1_
$a Jardon, Kelly M C $u R&D Group VitaK, Maastricht University, The Netherlands.
700    1_
$a Drummen, Nadja E A $u R&D Group VitaK, Maastricht University, The Netherlands.
700    1_
$a Vermeer, Cees $u R&D Group VitaK, Maastricht University, The Netherlands.
773    0_
$w MED00002857 $t The Journal of nutritional biochemistry $x 1873-4847 $g Roč. 46, č. - (2017), s. 83-89
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28486172 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180709 $b ABA008
991    __
$a 20180718111636 $b ABA008
999    __
$a ok $b bmc $g 1317169 $s 1021959
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 46 $c - $d 83-89 $e 20170422 $i 1873-4847 $m Journal of nutritional biochemistry $n J Nutr Biochem $x MED00002857
GRA    __
$a NV15-27109A $p MZ0
LZP    __
$a Pubmed-20180709

Najít záznam

Citační ukazatele

Možnosti archivace