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Bacillus Calmette-Guérin pneumonitis after intravesical instillation: Report of two cases and a review of the literature

M. Spisarova, S. Losse, P. Jakubec, I. Hartmann, M. Kral, J. Ehrmann, M. Szkorupa, H. Studentova, B. Melichar

. 2024 ; 168 (2) : 181-186. [pub] 20230102

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články, kazuistiky, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc24011932

OBJECTIVE: Intravesical administration of bacillus Calmette-Guérin is standard adjuvant treatment of non-muscle invasive bladder cancer. In spite of the fact that this immunotherapy is locoregional, there are still risk of some complications. METHODS: We describe two cases of systemic BCG infection after intravesical administration of BCG vaccine in patients with early stage of bladder cancer. RESULTS: Both patients suffered from systemic BCG infection manifesting as BCG pneumonitis. After standard therapy with antituberculotic agents, both of them fully recovered. CONCLUSION: BCG infection can occur as a rare but potentially serious complication of this treatment procedure. Gravity of this side effect and its specific therapy require prompt and right diagnosis.

Citace poskytuje Crossref.org

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