Acute portal vein thrombosis in noncirrhotic patients - different prognoses based on presence of inflammatory markers: a long-term multicenter retrospective analysis
Language English Country Great Britain, England Media print-electronic
Document type Comparative Study, Journal Article, Multicenter Study
- Keywords
- Acute portal vein thrombosis, hemato-oncologic disease, prothrombotic factors,
- MeSH
- Acute Disease MeSH
- Biomarkers blood MeSH
- C-Reactive Protein analysis MeSH
- Time Factors MeSH
- Middle Aged MeSH
- Humans MeSH
- Prognosis MeSH
- Retrospective Studies MeSH
- Portal Vein * MeSH
- Inflammation blood MeSH
- Venous Thrombosis blood diagnosis MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Comparative Study MeSH
- Names of Substances
- Biomarkers MeSH
- C-Reactive Protein MeSH
Background: Portal vein thrombosis (PVT) is a partial or complete thrombotic occlusion of the portal vein and is rare in noncirrhotic patients.Patients and methods: 78 adult patients with noncirrhotic acute PVT without known malignity were evaluated. Patients with initial CRP level 61-149 mg/l were excluded.Results: Patients were divided into two groups - the first one (33 patients) was characterized with signs of inflammation and CRP over 149 mg/l. The second group (45 patients) was without signs of inflammation and CRP level less than 61 mg/l. The frequency of prothrombotic hematologic factors was statistically significantly different in levels of factor VIII and MTHFR 677 C mutation. All patients from both groups underwent the same oncologic and hemato-oncologic screening which was positive in 23 patients (51.1%) in the group without signs of inflammation. In the group of patients with clinical and laboratory signs of inflammation oncologic and hemato-oncologic screening was positive only in 1 patient (3.0%). Complete portal vein recanalization was achieved in 19.2%, partial recanalization in 26.9%.Conclusions: Patients with clinical signs of inflammation and acute PVT have a low risk of malignancy in contrast to patients without signs of inflammation and acute PVT, which have a high risk of oncologic or hemato-oncologic disease. Patients with negative hemato-oncologic screening should be carefully observed over time because we expect they are at higher risk for the development of hemato-oncologic disease, independent from the presence and number of procoagulation risk factors.
3rd Department of Surgery Motol University Hospital Prague Czech Republic
Departement of Pediatric Surgery University Hospital Motol Prague Czech Republic
Department of 1st Internal Medicine University Hospital Pilsen Pilsen Czech Republic
Department of Hematology Motol University Hospital Prague Czech Republic
Department of Internal Medicine Motol University Hospital Prague Czech Republic
Department of Internal Medicine Tomas Bata Regional Hospital in Zlin Czech Republic
Department of Internal Medicine University Hospital in Brno Brno Czech Republic
Department of Surgery Motol University Hospital Prague Czech Republic
References provided by Crossref.org
